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Table 1 Sample characteristics and group differences in CSF biomarkers

From: Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study

N = 205 Total Sample HC (n = 76) HC vs. SCDb SCD (n = 105) SCD vs. Relb Relatives of AD (n = 24) HC vs. Relb F value/chi2 valuec
Age (in years, mean, SD) 68.9 (5.4) 68.3 (4.9) * 70.4 (5.5) *** 64.5 (3.7) ** 14.2***, p < 0.001
Sex (female; n, %) 107 (52.2) 42 (55.3)   48 (45.7) * 17 (70.8)   5.4, p = .07
Education (in years, mean, SD) 14.7 (2.9) 14.6 (2.8)   15.0 (3.1)   13.6 (2.5)   2.1, p = .12
MMSE (mean, SD) 29.26 (0.95) 29.4 (0.9)   29.2 (0.9)   28.9 (1.2)   2.38, p = .09
Word list recall (mean, SD) 7.5 (1.7) 7.9 (1.6)   7.3 (1.7)   7.1 (2.2)   2.97, p = .053
GDS (mean, SD) 1.27 (1.6) 0.7 (1.3) *** 1.8 (1.8) ** 1.0 (1.5)   13.05***, p < 0.001
APOE genotype
 APOE4 genotype of all APOE (n, %) 53 (25.9) 15 (21.4)   31 (33.7)   7 (43.8)   4.50, p = 0.105
CSF biomarkersa
 Aß42 (pg/ml; mean, SD) 768.55 (313.89) 851.80 (301.55) ** 708.64 (316.88)   767.00 (289.93)   4.23*, p < .05
 Aß42/Tau ratio (mean, SD) 1.15 (0.48) 1.28 (0.47) ** 1.06 (0.49)   1.14 (0.40)   4.02*, p < .05
 Total Tau (mean, SD) 393.46 (175.63) 384.73 (165.199)   404.506 (195.333)   372.799 (103.895)   0.081, p = .923
 p-Tau-181 (pg/ml; mean, SD) 51.00 (20.82) 51.22 (18.51)   51.73 (23.94)   46.81 (12.32)   0.94, p = .940
  1. Bonferroni adjusted p values; p value = .05, two-tailed sign
  2. SD standard deviation, MMSE Mini-Mental State Examination, GDS Geriatric Depression Scale, HC Healthy Controls
  3. *Significant results on the α < .05 level
  4. **Significant results on the α < .01 level
  5. ***Significant results on the α < .001 level
  6. aTests of CSF biomarkers are adjusted for age
  7. bPost hoc t tests for continuous and chi2 tests for categorical variables (sex and APOE4)
  8. cF values were presented for continuous variables, chi2 values for categorical variables (sex and APOE4)