Cross-sectional and longitudinal characterization of SCD patients recruited from the community versus from a memory clinic: subjective cognitive decline, psychoaffective factors, cognitive performances, and atrophy progression over time

Table 3 Description of the progression over time of SCD, cognitive, and psychoaffective measures within each group

Scores	N	SCD-community	N	SCD-clinic	ANCOVAs, p value
Follow-up duration, years (behavioural measures)	22	2.45 ± 0.67	25	2.36 ± 0.95	0.32
Follow-up duration, years (neuroimaging measures—MRI)	22	2.55 ± 0.67	24	2.28 ± 0.78	0.22
Self-reported SCD slopes
Global_R	22	− 0.08 ± 0.27	20	0.08 ± 0.35	0.11
Attention-language (F1)	22	0.009 ± 0.06	20	0.02 ± 0.11	0.60
Memory-orientation (F2)	22	− 0.03 ± 0.09	20	0.004 ± 0.12	0.28
Praxis-domestic activities (F3)	22	− 0.009 ± 0.07	20	0.04 ± 0.09^#	0.04
Informant-reported SCD slopes
Global_R	15	0.06 ± 0.46	16	0.07 ± 0.65	0.98
Attention-language (F1)	15	− 0.02 ± 0.13	16	0.01 ± 0.2	0.65
Memory-orientation (F2)	15	0.02 ± 0.12	16	− 0.007 ± 0.12	0.61
Praxis-domestic activities (F3)	15	0.03 ± 0.15	16	0.02 ± 0.1	0.94
Slope of cognitive change
DRS	22	− 0.02 ± 0.14	25	− 0.03 ± 0.11	0.74
ESR	22	0.0005 ± 0.03	24	− 0.02 ± 0.09	0.27
Slope of psychoaffective changes
STAI-B	22	− 0.04 ± 0.21	25	0.05 ± 0.22	0.16
MADRS	22	0.09 ± 0.20	23	0.08 ± 0.26	0.92

The values indicate the mean ± SD of the slope of evolution between baseline and follow-up. When ANCOVAs correcting for age and education reached significance, values are indicated in italics (p < 0.05)
Abbreviations: ANCOVAs analyses of covariance correcting for age and education, CDS Cognitive Difficulties Scale, DRS Mattis Dementia Rating Scale, ESR Encoding, Storage and Recuperation, F1 factor 1 attention-language SCD, F2 factor 2 memory-orientation SCD, F3 factor 3 praxis-domestic activities SCD, HC healthy control, MADRS Montgomery-Asberg Depression Rating Scale, MRI magnetic resonance imaging, N sample size, SCD subjective cognitive decline, SD standardized deviation, STAI-B Spielberger State-Anxiety Inventory Trait
^#The slope is significantly different from zero (p < 0.05)

ISSN: 1758-9193