Skip to main content

Advertisement

Table 1 Proteins overrepresented in Aβ-enriched fraction and proteins overrepresented in non-AD samples. The MS/MS raw files were examined against the universal protein database UniProt (70,931 entries in January 2019) (http://www.uniprot.org), using the SEQUEST algorithm (Proteome Discoverer 1.4, Thermo Fisher Scientific). Fold of change; P value < 0.05. PSM peptide-spectrum matches, average, ND-AD not detected in Alzheimer extracts, ND-non-AD not detected in control extracts

From: Human amyloid-β enriched extracts: evaluation of in vitro and in vivo internalization and molecular characterization

Symbol Entrez gene name ID PSM non-AD1 PSM non-AD2 PSM AD1 PSM AD2 x̄ non-AD x̄ AD Fold of change p value
A) Proteins overrepresented in AD enriched fractions
GFAP Glial fibrillary acidic protein P14136 36 48 71 100 42 85.5 2.04 1E−4
MBP Myelin basic protein J3QL64 11 14 41 17 12.5 29 2.32 0.013
SH2D3C SH2 domain-containing protein 3C (fragment) Q5JU32 19 2 47 2 10.5 24.5 2.33 0.019
ANXA5 Annexin A5 P08758 0 0 4 15 0 9.5 ND–non AD 0.001
HIST1H2BK Histone H2B type 1-K O60814 0 0 9 1 0 5 ND–non AD 0.025
ANXA2 Annexin A2 H0YMM1 0 0 2 6 0 4 ND–non AD 0.045
B) Proteins overrepresented in non-AD enriched fractions
COL6A3 Collagen alpha-3(VI) chain E7ENL6 13 28 0 7 20.5 3.5 5.86 6E−4
FGB Fibrinogen beta chain P02675 15 23 0 15 19 7.5 2.53 0.034
FN1 Fibronectin P02751 2 5 0 0 3.5 0 ND–AD 0.045