Table 1 Characteristics of participants by ATN(F) biomarker classification
From: FDG-PET as an independent biomarker for Alzheimer’s biological diagnosis: a longitudinal study
Characteristics | A+T+N−F− | A+T+N−F+ | A+T+N+F− | A+T+N+F+ |
|---|---|---|---|---|
n | 132 | 102 | 113 | 204 |
Age (years) | 73.21 ± 6.08 | 74.46 ± 7.38 | 74.09 ± 7.44 | 74.02 ± 7.59 |
Female (%) | 59(45%) | 34(33%) | 63(56%) | 92(45%) |
Educational level (years) | 16.31 ± 2.35 | 16.23 ± 2.89 | 15.57 ± 2.69 | 15.70 ± 2.94 |
APOE ε4 positive (%) | 77(58%) | 64(63%) | 72(64%) | 151(74%) |
Cognitive score | ||||
MMSE | 28.21 ± 1.87 | 26.31 ± 2.56 | 27.62 ± 2.17 | 25.06 ± 2.89 |
RAVLT-immediate recall | 37.98 ± 10.58 | 29.81 ± 10.22 | 35.29 ± 9.62 | 26.16 ± 9.87 |
RAVLT-delayed recall | 3.48 ± 4.02 | 3.76 ± 4.13 | 3.51 ± 4.02 | 3.56 ± 4.05 |
Brain structure | ||||
MTL volume (mm3) | 20,603.68 ± 2852.81 | 19,230.37 ± 2999.68 | 20,078.17 ± 2789.14 | 17,863.85 ± 2891.62 |
EC thickness (mm) | 3724.40 ± 635.16 | 3237.51 ± 715.711 | 3548.83 ± 738.51 | 3117.98 ± 724.23 |
Ventricular volume (mm3) | 36,744.74 ± 18,700.67 | 55,002.57 ± 23,690.36 | 32,262.09 ± 18,079.57 | 42,955.53 ± 20,601.77 |
CSF Aβ (pg/ml) | 142.71 ± 26.92 | 134.03 ± 25.24 | 136.06 ± 20.82 | 131.30 ± 22.54 |
CSF P-tau (pg/ml) | 40.60 ± 15.28 | 41.69 ± 17.18 | 58.35 ± 22.56 | 62.99 ± 30.94 |
CSF T-tau (pg/ml) | 67.05 ± 16.43 | 70.81 ± 15.45 | 142.66 ± 46.12 | 154.35 ± 55.96 |
FDG-PET | 1.34 ± 0.09 | 1.09 ± 0.09 | 1.33 ± 0.09 | 1.07 ± 0.10 |