Fig. 6

HtauE14 release and uptake by neurons and microglia in an old AD rat. a HT7 staining in a 21-month-old rat, 7 months post-infusion. Scale bar, 200 μm. b Enlargement of a region in the corpus callosum (CC) in A. c Enlargement of a region in the sensory cortex (SC) in A. d1–d3 GFP⁺ cells in the CC and some co-localization with Iba-1⁺ microglia. e1–e3 GFP⁺ cells in the sensory cortex (SC) and some co-localization with Iba-1⁺ microglia. f1–f3 No co-localization of GFP and GFAP⁺ cells. g1–g3 GFP⁺ cells in the SC co-localized with NeuN. Scale bars, 50 μm