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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: An experimental model of Braak’s pretangle proposal for the origin of Alzheimer’s disease: the role of locus coeruleus in early symptom development

Fig. 2

No odor discrimination deficiency or LC degeneration in young 6-month-old rats infused with htauE14 at 2–3 months old. a Schematics of the time course of the AAV infusion, odor discrimination training, and histology. b Simple odor discrimination (SOD) training using dissimilar odors. c Difficult odor discrimination (DOD) training using similar odor pairs. (N: htau/control: 6/4). d–f LC cell counts in htauE14 and control rats. (N: htau/control: 5/5). g–i NET fibers (red) in the piriform cortex (PC). (N: htau/control: 6/5). j–l DBH fibers (red) in the PC. (N: htau/control: 6/5). m–o Iba-1 cell staining (red) in the PC. (N: htau/control: 6/5). Scale bars, 50 μm

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Alzheimer's Research & Therapy

ISSN: 1758-9193