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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Upregulation of MIF as a defense mechanism and a biomarker of Alzheimer’s disease

Fig. 3

MIF deficiency affects cognitive functions in the AD model mice. APP23/MIF+/− and APP23 mice (APP/MIF+/− and APP, respectively) at the age of 12 to 13 months were subjected to the Morris water maze test. a During the first day of visible platform tests, the APP23/MIF+/− and APP23 mice exhibited a similar latency to escape onto the visible platform. P > 0.05 by Student’s t test. b APP23/MIF+/− and APP23 mice had similar swimming distances before escaping onto the visible platform. P > 0.05 by Student’s t test. c In hidden platform tests, APP23/MIF+/− mice showed a longer latency to escape on to the hidden platform on the 5th day. *p < 0.05 by two-way ANOVA with Bonferroni post hoc tests. d APP23/MIF+/− mice had a shorter swimming length before escaping onto the hidden platform on the 5th day. *P < 0.05 by two-way ANOVA with Bonferroni post hoc tests. e On the last day of the trial, APP23/MIF+/− showed a significantly lower number of passing times through the location of the platform than APP23 mice. P < 0.05 by Student’s t test

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