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Table 3 Intervention effects on cognition—sub-group analyses by baseline MRI measures

From: Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)

  Difference between the intervention and control groups per year (randomization group × time) Difference between MRI > median and MRI < median (randomization group × time × MRI)
Estimate (95% CI) p Estimate (95% CI) p
NTB total score (primary outcome)
 *Hippocampal volume >median 0.056 (− 0.034–0.146) 0.225 0.030 (− 0.100–0.156) 0.668
<median 0.028 (− 0.063–0.119) 0.551
 AD signature cortical thickness >median 0.092 (0.002–0.181) 0.044 0.097 (− 0.029–0.222) 0.131
<median − 0.005 (− 0.093–0.083) 0.915
 *Total GM volume >median 0.018 (− 0.072–0.108) 0.701 − 0.055 (− 0.184–0.073) 0.397
<median 0.073 (− 0.020–0.160) 0.117
 *WML volume >median 0.025 (− 0.063–0.113) 0.576 − 0.053 (− 0.178–0.073) 0.411
<median 0.078 (− 0.012–0.170) 0.088
Processing speed (secondary outcome)
 *Hippocampal volume >median 0.144 (0.024–0.263) 0.018 0.149 (− 0.020–0.320) 0.085
<median − 0.006 (− 0.130–0.115) 0.927
 AD signature cortical thickness >median 0.170 (0.050–0.290) 0.005 0.198 (0.030–0.365) 0.021
<median − 0.030 (− 0.146–0.090) 0.641
 *Total GM volume >median 0.075 (− 0.044–0.194) 0.217 − 0.002 (− 0.172–0.170) 0.980
<median 0.077 (− 0.044–0.198) 0.212
 *WML volume >median 0.054 (− 0.070–0.174) 0.379 − 0.110 (− 0.280–0.060) 0.208
<median 0.164 (0.042–0.290) 0.009
Memory (secondary outcome)
 *Hippocampal volume >median 0.040 (− 0.107–0.190) 0.586 − 0.046 (− 0.257–0.166) 0.671
<median 0.087 (− 0.063–0.237) 0.256
 AD signature cortical thickness >median 0.086 (− 0.062–0.234) 0.255 0.040 (− 0.168–0.250) 0.706
<median 0.046 (− 0.100–0.192) 0.539
 *Total GM volume >median 0.010 (− 0.140–0.160) 0.891 − 0.113 (− 0.325–0.100) 0.297
<median 0.123 (− 0.028–0.270) 0.110
 *WML volume >median 0.025 (− 0.130–0.179) 0.749 − 0.030 (− 0.248–0.190) 0.795
<median 0.054 (− 0.102–0.210) 0.497
Executive functioning (secondary outcome)
 *Hippocampal volume >median 0.028 (− 0.073–0.128) 0.591 0.026 (− 0.117–0.170) 0.717
<median 0.001 (− 0.100–0.103) 0.982
 AD signature cortical thickness >median 0.070 (− 0.035–0.169) 0.197 0.100 (− 0.042–0.240) 0.169
<median − 0.033 (− 0.134–0.070) 0.515
 *Total GM volume >median − 0.006 (− 0.107–0.095) 0.909 − 0.048 (− 0.190–0.096) 0.514
<median 0.042 (− 0.060–0.144) 0.422
 *WML volume >median 0.021 (− 0.085–0.128) 0.693 − 0.048(− 0.200–0.105) 0.540
<median 0.069 (− 0.039–0.178) 0.213
  1. AD signature cortical thickness: cortical thickness in AD signature regions calculated as the average of cortical thickness in entorhinal, inferior temporal, middle temporal, and fusiform regions as previously described [38]
  2. NTB neuropsychological test battery, GM gray matter, WML white matter lesions
  3. *For all volumetric measures, medians of TIV-normalized values were used
  4. Values in bold represent p-value < 0.05; values in italics represent p-value < 0.10