Difference between the intervention and control groups per year (randomization group × time) | Difference between MRI > median and MRI < median (randomization group × time × MRI) | ||||
---|---|---|---|---|---|
Estimate (95% CI) | p | Estimate (95% CI) | p | ||
NTB total score (primary outcome) | |||||
*Hippocampal volume | >median | 0.056 (− 0.034–0.146) | 0.225 | 0.030 (− 0.100–0.156) | 0.668 |
<median | 0.028 (− 0.063–0.119) | 0.551 | |||
AD signature cortical thickness | >median | 0.092 (0.002–0.181) | 0.044 | 0.097 (− 0.029–0.222) | 0.131 |
<median | − 0.005 (− 0.093–0.083) | 0.915 | |||
*Total GM volume | >median | 0.018 (− 0.072–0.108) | 0.701 | − 0.055 (− 0.184–0.073) | 0.397 |
<median | 0.073 (− 0.020–0.160) | 0.117 | |||
*WML volume | >median | 0.025 (− 0.063–0.113) | 0.576 | − 0.053 (− 0.178–0.073) | 0.411 |
<median | 0.078 (− 0.012–0.170) | 0.088 | |||
Processing speed (secondary outcome) | |||||
*Hippocampal volume | >median | 0.144 (0.024–0.263) | 0.018 | 0.149 (− 0.020–0.320) | 0.085 |
<median | − 0.006 (− 0.130–0.115) | 0.927 | |||
AD signature cortical thickness | >median | 0.170 (0.050–0.290) | 0.005 | 0.198 (0.030–0.365) | 0.021 |
<median | − 0.030 (− 0.146–0.090) | 0.641 | |||
*Total GM volume | >median | 0.075 (− 0.044–0.194) | 0.217 | − 0.002 (− 0.172–0.170) | 0.980 |
<median | 0.077 (− 0.044–0.198) | 0.212 | |||
*WML volume | >median | 0.054 (− 0.070–0.174) | 0.379 | − 0.110 (− 0.280–0.060) | 0.208 |
<median | 0.164 (0.042–0.290) | 0.009 | |||
Memory (secondary outcome) | |||||
*Hippocampal volume | >median | 0.040 (− 0.107–0.190) | 0.586 | − 0.046 (− 0.257–0.166) | 0.671 |
<median | 0.087 (− 0.063–0.237) | 0.256 | |||
AD signature cortical thickness | >median | 0.086 (− 0.062–0.234) | 0.255 | 0.040 (− 0.168–0.250) | 0.706 |
<median | 0.046 (− 0.100–0.192) | 0.539 | |||
*Total GM volume | >median | 0.010 (− 0.140–0.160) | 0.891 | − 0.113 (− 0.325–0.100) | 0.297 |
<median | 0.123 (− 0.028–0.270) | 0.110 | |||
*WML volume | >median | 0.025 (− 0.130–0.179) | 0.749 | − 0.030 (− 0.248–0.190) | 0.795 |
<median | 0.054 (− 0.102–0.210) | 0.497 | |||
Executive functioning (secondary outcome) | |||||
*Hippocampal volume | >median | 0.028 (− 0.073–0.128) | 0.591 | 0.026 (− 0.117–0.170) | 0.717 |
<median | 0.001 (− 0.100–0.103) | 0.982 | |||
AD signature cortical thickness | >median | 0.070 (− 0.035–0.169) | 0.197 | 0.100 (− 0.042–0.240) | 0.169 |
<median | − 0.033 (− 0.134–0.070) | 0.515 | |||
*Total GM volume | >median | − 0.006 (− 0.107–0.095) | 0.909 | − 0.048 (− 0.190–0.096) | 0.514 |
<median | 0.042 (− 0.060–0.144) | 0.422 | |||
*WML volume | >median | 0.021 (− 0.085–0.128) | 0.693 | − 0.048(− 0.200–0.105) | 0.540 |
<median | 0.069 (− 0.039–0.178) | 0.213 |