NTB total score (primary outcome)

*Hippocampal volume

>median

0.056 (− 0.034–0.146)

0.225

0.030 (− 0.100–0.156)

0.668

<median

0.028 (− 0.063–0.119)

0.551

AD signature cortical thickness

>median

0.092 (0.002–0.181)

0.044

0.097 (− 0.029–0.222)

0.131

<median

− 0.005 (− 0.093–0.083)

0.915

*Total GM volume

>median

0.018 (− 0.072–0.108)

0.701

− 0.055 (− 0.184–0.073)

0.397

<median

0.073 (− 0.020–0.160)

0.117

*WML volume

>median

0.025 (− 0.063–0.113)

0.576

− 0.053 (− 0.178–0.073)

0.411

<median

0.078 (− 0.012–0.170)

0.088

Processing speed (secondary outcome)

*Hippocampal volume

>median

0.144 (0.024–0.263)

0.018

0.149 (− 0.020–0.320)

0.085

<median

− 0.006 (− 0.130–0.115)

0.927

AD signature cortical thickness

>median

0.170 (0.050–0.290)

0.005

0.198 (0.030–0.365)

0.021

<median

− 0.030 (− 0.146–0.090)

0.641

*Total GM volume

>median

0.075 (− 0.044–0.194)

0.217

− 0.002 (− 0.172–0.170)

0.980

<median

0.077 (− 0.044–0.198)

0.212

*WML volume

>median

0.054 (− 0.070–0.174)

0.379

− 0.110 (− 0.280–0.060)

0.208

<median

0.164 (0.042–0.290)

0.009

Memory (secondary outcome)

*Hippocampal volume

>median

0.040 (− 0.107–0.190)

0.586

− 0.046 (− 0.257–0.166)

0.671

<median

0.087 (− 0.063–0.237)

0.256

AD signature cortical thickness

>median

0.086 (− 0.062–0.234)

0.255

0.040 (− 0.168–0.250)

0.706

<median

0.046 (− 0.100–0.192)

0.539

*Total GM volume

>median

0.010 (− 0.140–0.160)

0.891

− 0.113 (− 0.325–0.100)

0.297

<median

0.123 (− 0.028–0.270)

0.110

*WML volume

>median

0.025 (− 0.130–0.179)

0.749

− 0.030 (− 0.248–0.190)

0.795

<median

0.054 (− 0.102–0.210)

0.497

Executive functioning (secondary outcome)

*Hippocampal volume

>median

0.028 (− 0.073–0.128)

0.591

0.026 (− 0.117–0.170)

0.717

<median

0.001 (− 0.100–0.103)

0.982

AD signature cortical thickness

>median

0.070 (− 0.035–0.169)

0.197

0.100 (− 0.042–0.240)

0.169

<median

− 0.033 (− 0.134–0.070)

0.515

*Total GM volume

>median

− 0.006 (− 0.107–0.095)

0.909

− 0.048 (− 0.190–0.096)

0.514

<median

0.042 (− 0.060–0.144)

0.422

*WML volume

>median

0.021 (− 0.085–0.128)

0.693

− 0.048(− 0.200–0.105)

0.540

<median

0.069 (− 0.039–0.178)

0.213
