NTB total score (primary outcome)
|
*Hippocampal volume
|
>median
|
0.056 (− 0.034–0.146)
|
0.225
|
0.030 (− 0.100–0.156)
|
0.668
|
<median
|
0.028 (− 0.063–0.119)
|
0.551
|
AD signature cortical thickness
|
>median
|
0.092 (0.002–0.181)
|
0.044
|
0.097 (− 0.029–0.222)
|
0.131
|
<median
|
− 0.005 (− 0.093–0.083)
|
0.915
|
*Total GM volume
|
>median
|
0.018 (− 0.072–0.108)
|
0.701
|
− 0.055 (− 0.184–0.073)
|
0.397
|
<median
|
0.073 (− 0.020–0.160)
|
0.117
|
*WML volume
|
>median
|
0.025 (− 0.063–0.113)
|
0.576
|
− 0.053 (− 0.178–0.073)
|
0.411
|
<median
|
0.078 (− 0.012–0.170)
|
0.088
|
Processing speed (secondary outcome)
|
*Hippocampal volume
|
>median
|
0.144 (0.024–0.263)
|
0.018
|
0.149 (− 0.020–0.320)
|
0.085
|
<median
|
− 0.006 (− 0.130–0.115)
|
0.927
|
AD signature cortical thickness
|
>median
|
0.170 (0.050–0.290)
|
0.005
|
0.198 (0.030–0.365)
|
0.021
|
<median
|
− 0.030 (− 0.146–0.090)
|
0.641
|
*Total GM volume
|
>median
|
0.075 (− 0.044–0.194)
|
0.217
|
− 0.002 (− 0.172–0.170)
|
0.980
|
<median
|
0.077 (− 0.044–0.198)
|
0.212
|
*WML volume
|
>median
|
0.054 (− 0.070–0.174)
|
0.379
|
− 0.110 (− 0.280–0.060)
|
0.208
|
<median
|
0.164 (0.042–0.290)
|
0.009
|
Memory (secondary outcome)
|
*Hippocampal volume
|
>median
|
0.040 (− 0.107–0.190)
|
0.586
|
− 0.046 (− 0.257–0.166)
|
0.671
|
<median
|
0.087 (− 0.063–0.237)
|
0.256
|
AD signature cortical thickness
|
>median
|
0.086 (− 0.062–0.234)
|
0.255
|
0.040 (− 0.168–0.250)
|
0.706
|
<median
|
0.046 (− 0.100–0.192)
|
0.539
|
*Total GM volume
|
>median
|
0.010 (− 0.140–0.160)
|
0.891
|
− 0.113 (− 0.325–0.100)
|
0.297
|
<median
|
0.123 (− 0.028–0.270)
|
0.110
|
*WML volume
|
>median
|
0.025 (− 0.130–0.179)
|
0.749
|
− 0.030 (− 0.248–0.190)
|
0.795
|
<median
|
0.054 (− 0.102–0.210)
|
0.497
|
Executive functioning (secondary outcome)
|
*Hippocampal volume
|
>median
|
0.028 (− 0.073–0.128)
|
0.591
|
0.026 (− 0.117–0.170)
|
0.717
|
<median
|
0.001 (− 0.100–0.103)
|
0.982
|
AD signature cortical thickness
|
>median
|
0.070 (− 0.035–0.169)
|
0.197
|
0.100 (− 0.042–0.240)
|
0.169
|
<median
|
− 0.033 (− 0.134–0.070)
|
0.515
|
*Total GM volume
|
>median
|
− 0.006 (− 0.107–0.095)
|
0.909
|
− 0.048 (− 0.190–0.096)
|
0.514
|
<median
|
0.042 (− 0.060–0.144)
|
0.422
|
*WML volume
|
>median
|
0.021 (− 0.085–0.128)
|
0.693
|
− 0.048(− 0.200–0.105)
|
0.540
|
<median
|
0.069 (− 0.039–0.178)
|
0.213
|