Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)

Ruth Stephen; Yawu Liu; Tiia Ngandu; Riitta Antikainen; Juha Hulkkonen; Juha Koikkalainen; Nina Kemppainen; Jyrki Lötjönen; Esko Levälahti; Riitta Parkkola; Pauliina Pippola; Juha Rinne; Timo Strandberg; Jaakko Tuomilehto; Ritva Vanninen; Miia Kivipelto; Hilkka Soininen; Alina Solomon

doi:10.1186/s13195-019-0506-z

Table 3 Intervention effects on cognition—sub-group analyses by baseline MRI measures

From: Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)

		Difference between the intervention and control groups per year (randomization group × time)		Difference between MRI > median and MRI < median (randomization group × time × MRI)
		Estimate (95% CI)	p	Estimate (95% CI)	p
NTB total score (primary outcome)
*Hippocampal volume	>median	0.056 (− 0.034–0.146)	0.225	0.030 (− 0.100–0.156)	0.668
*Hippocampal volume	<median	0.028 (− 0.063–0.119)	0.551	0.030 (− 0.100–0.156)	0.668
AD signature cortical thickness	>median	0.092 (0.002–0.181)	0.044	0.097 (− 0.029–0.222)	0.131
AD signature cortical thickness	<median	− 0.005 (− 0.093–0.083)	0.915	0.097 (− 0.029–0.222)	0.131
*Total GM volume	>median	0.018 (− 0.072–0.108)	0.701	− 0.055 (− 0.184–0.073)	0.397
*Total GM volume	<median	0.073 (− 0.020–0.160)	0.117	− 0.055 (− 0.184–0.073)	0.397
*WML volume	>median	0.025 (− 0.063–0.113)	0.576	− 0.053 (− 0.178–0.073)	0.411
*WML volume	<median	0.078 (− 0.012–0.170)	0.088	− 0.053 (− 0.178–0.073)	0.411
Processing speed (secondary outcome)
*Hippocampal volume	>median	0.144 (0.024–0.263)	0.018	0.149 (− 0.020–0.320)	0.085
*Hippocampal volume	<median	− 0.006 (− 0.130–0.115)	0.927	0.149 (− 0.020–0.320)	0.085
AD signature cortical thickness	>median	0.170 (0.050–0.290)	0.005	0.198 (0.030–0.365)	0.021
AD signature cortical thickness	<median	− 0.030 (− 0.146–0.090)	0.641	0.198 (0.030–0.365)	0.021
*Total GM volume	>median	0.075 (− 0.044–0.194)	0.217	− 0.002 (− 0.172–0.170)	0.980
*Total GM volume	<median	0.077 (− 0.044–0.198)	0.212	− 0.002 (− 0.172–0.170)	0.980
*WML volume	>median	0.054 (− 0.070–0.174)	0.379	− 0.110 (− 0.280–0.060)	0.208
*WML volume	<median	0.164 (0.042–0.290)	0.009	− 0.110 (− 0.280–0.060)	0.208
Memory (secondary outcome)
*Hippocampal volume	>median	0.040 (− 0.107–0.190)	0.586	− 0.046 (− 0.257–0.166)	0.671
*Hippocampal volume	<median	0.087 (− 0.063–0.237)	0.256	− 0.046 (− 0.257–0.166)	0.671
AD signature cortical thickness	>median	0.086 (− 0.062–0.234)	0.255	0.040 (− 0.168–0.250)	0.706
AD signature cortical thickness	<median	0.046 (− 0.100–0.192)	0.539	0.040 (− 0.168–0.250)	0.706
*Total GM volume	>median	0.010 (− 0.140–0.160)	0.891	− 0.113 (− 0.325–0.100)	0.297
*Total GM volume	<median	0.123 (− 0.028–0.270)	0.110	− 0.113 (− 0.325–0.100)	0.297
*WML volume	>median	0.025 (− 0.130–0.179)	0.749	− 0.030 (− 0.248–0.190)	0.795
*WML volume	<median	0.054 (− 0.102–0.210)	0.497	− 0.030 (− 0.248–0.190)	0.795
Executive functioning (secondary outcome)
*Hippocampal volume	>median	0.028 (− 0.073–0.128)	0.591	0.026 (− 0.117–0.170)	0.717
*Hippocampal volume	<median	0.001 (− 0.100–0.103)	0.982	0.026 (− 0.117–0.170)	0.717
AD signature cortical thickness	>median	0.070 (− 0.035–0.169)	0.197	0.100 (− 0.042–0.240)	0.169
AD signature cortical thickness	<median	− 0.033 (− 0.134–0.070)	0.515	0.100 (− 0.042–0.240)	0.169
*Total GM volume	>median	− 0.006 (− 0.107–0.095)	0.909	− 0.048 (− 0.190–0.096)	0.514
*Total GM volume	<median	0.042 (− 0.060–0.144)	0.422	− 0.048 (− 0.190–0.096)	0.514
*WML volume	>median	0.021 (− 0.085–0.128)	0.693	− 0.048(− 0.200–0.105)	0.540
*WML volume	<median	0.069 (− 0.039–0.178)	0.213	− 0.048(− 0.200–0.105)	0.540

AD signature cortical thickness: cortical thickness in AD signature regions calculated as the average of cortical thickness in entorhinal, inferior temporal, middle temporal, and fusiform regions as previously described [38]
NTB neuropsychological test battery, GM gray matter, WML white matter lesions
*For all volumetric measures, medians of TIV-normalized values were used
Values in bold represent p-value < 0.05; values in italics represent p-value < 0.10

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