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Table 2 MRI measures at baseline, follow-up, and annual rate of change

From: Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)

MRI measures Total, n Intervention, n = 59 Control, n = 53 p
Total intracranial volume, ml 112 1581.4 (1112.4–2039.1) 1524.4 (975.5–1962.1) 0.13
Baseline
 Total hippocampal volume, ml 112 7.2 (4.6–9.1) 7.0 (4.5–8.3) 0.33
 AD signature cortical thickness, mm 112 2.8 (2.5–3.0) 2.8 (2.5–3.1) 0.87
 Total GM volume, ml 112 576.7 (443.4–677.3) 563.4 (406.3–709.6) 0.18
 WML volume, ml 100 11.9 (0.5–60.7) 11.7 (0.7–74.4) 0.95
2-year follow-up
 Total hippocampal volume, ml 112 7.0 (4.3–9.1) 6.8 (4.1–8.3) 0.27
 AD signature cortical thickness, mm 112 2.7 (2.5–3.1) 2.7 (2.3–3.1) 0.47
 Total GM volume, ml 112 568.6 (434.4–670.4) 556.0 (414.8–698.5) 0.19
 WML volume, ml 100 13.6 (0.4–59.9) 13.0 (0.5–84.9) 0.86
*Annual rate of change, % (SD)
 Total hippocampal volume 112 − 1.30 (1.3) − 1.50 (2.0) 0.56
 AD signature cortical thickness 112 − 0.68 (0.98) − 0.39 (1.2) 0.24
 Total GM volume 112 − 0.70 (0.89) − 0.60 (1.4) 0.64
 WML volume 96 7.0 (28.4) 11.6 (50.3) 0.58
  1. MRI values are mean (minimum–maximum). All MRI measures are based on longitudinal FreeSurfer analyses. AD signature cortical thickness: cortical thickness in AD signature regions calculated as the average of cortical thickness in entorhinal, inferior temporal, middle temporal, and fusiform regions as previously described [38]
  2. GM gray matter, WML white matter lesions
  3. *Annual rate of change was calculated as (24-month value − baseline value)/(baseline value × time)