Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)

Table 2 MRI measures at baseline, follow-up, and annual rate of change

MRI measures	Total, n	Intervention, n = 59	Control, n = 53	p
Total intracranial volume, ml	112	1581.4 (1112.4–2039.1)	1524.4 (975.5–1962.1)	0.13
Baseline
Total hippocampal volume, ml	112	7.2 (4.6–9.1)	7.0 (4.5–8.3)	0.33
AD signature cortical thickness, mm	112	2.8 (2.5–3.0)	2.8 (2.5–3.1)	0.87
Total GM volume, ml	112	576.7 (443.4–677.3)	563.4 (406.3–709.6)	0.18
WML volume, ml	100	11.9 (0.5–60.7)	11.7 (0.7–74.4)	0.95
2-year follow-up
Total hippocampal volume, ml	112	7.0 (4.3–9.1)	6.8 (4.1–8.3)	0.27
AD signature cortical thickness, mm	112	2.7 (2.5–3.1)	2.7 (2.3–3.1)	0.47
Total GM volume, ml	112	568.6 (434.4–670.4)	556.0 (414.8–698.5)	0.19
WML volume, ml	100	13.6 (0.4–59.9)	13.0 (0.5–84.9)	0.86
*Annual rate of change, % (SD)
Total hippocampal volume	112	− 1.30 (1.3)	− 1.50 (2.0)	0.56
AD signature cortical thickness	112	− 0.68 (0.98)	− 0.39 (1.2)	0.24
Total GM volume	112	− 0.70 (0.89)	− 0.60 (1.4)	0.64
WML volume	96	7.0 (28.4)	11.6 (50.3)	0.58

MRI values are mean (minimum–maximum). All MRI measures are based on longitudinal FreeSurfer analyses. AD signature cortical thickness: cortical thickness in AD signature regions calculated as the average of cortical thickness in entorhinal, inferior temporal, middle temporal, and fusiform regions as previously described [38]
GM gray matter, WML white matter lesions
*Annual rate of change was calculated as (24-month value − baseline value)/(baseline value × time)