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Table 2 MRI measures at baseline, follow-up, and annual rate of change

From: Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)

MRI measures

Total, n

Intervention, n = 59

Control, n = 53

p

Total intracranial volume, ml

112

1581.4 (1112.4–2039.1)

1524.4 (975.5–1962.1)

0.13

Baseline

 Total hippocampal volume, ml

112

7.2 (4.6–9.1)

7.0 (4.5–8.3)

0.33

 AD signature cortical thickness, mm

112

2.8 (2.5–3.0)

2.8 (2.5–3.1)

0.87

 Total GM volume, ml

112

576.7 (443.4–677.3)

563.4 (406.3–709.6)

0.18

 WML volume, ml

100

11.9 (0.5–60.7)

11.7 (0.7–74.4)

0.95

2-year follow-up

 Total hippocampal volume, ml

112

7.0 (4.3–9.1)

6.8 (4.1–8.3)

0.27

 AD signature cortical thickness, mm

112

2.7 (2.5–3.1)

2.7 (2.3–3.1)

0.47

 Total GM volume, ml

112

568.6 (434.4–670.4)

556.0 (414.8–698.5)

0.19

 WML volume, ml

100

13.6 (0.4–59.9)

13.0 (0.5–84.9)

0.86

*Annual rate of change, % (SD)

 Total hippocampal volume

112

− 1.30 (1.3)

− 1.50 (2.0)

0.56

 AD signature cortical thickness

112

− 0.68 (0.98)

− 0.39 (1.2)

0.24

 Total GM volume

112

− 0.70 (0.89)

− 0.60 (1.4)

0.64

 WML volume

96

7.0 (28.4)

11.6 (50.3)

0.58

  1. MRI values are mean (minimum–maximum). All MRI measures are based on longitudinal FreeSurfer analyses. AD signature cortical thickness: cortical thickness in AD signature regions calculated as the average of cortical thickness in entorhinal, inferior temporal, middle temporal, and fusiform regions as previously described [38]
  2. GM gray matter, WML white matter lesions
  3. *Annual rate of change was calculated as (24-month value − baseline value)/(baseline value × time)