Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)

Ruth Stephen; Yawu Liu; Tiia Ngandu; Riitta Antikainen; Juha Hulkkonen; Juha Koikkalainen; Nina Kemppainen; Jyrki Lötjönen; Esko Levälahti; Riitta Parkkola; Pauliina Pippola; Juha Rinne; Timo Strandberg; Jaakko Tuomilehto; Ritva Vanninen; Miia Kivipelto; Hilkka Soininen; Alina Solomon

doi:10.1186/s13195-019-0506-z

Table 1 Characteristics of the intervention and control groups (participants with baseline MRI measurements)

From: Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)

Characteristics at baseline	Total, n	Intervention, n = 68	Control, n = 64	p
Demographic characteristics
Age at the baseline visit (years)	132	70.3	69.8	0.50
Sex (women, %)	132	29 (42.6)	33 (51.5)	0.30
Education (years)	132	9.3 (2.9)	9.2 (2.6)	0.87
Baseline vascular factors
Systolic blood pressure (mmHg)	129	139.6 (15.9)	139.0 (14.7)	0.83
Diastolic blood pressure (mmHg)	129	79.4 (8.9)	78.6 (8.9)	0.61
Fasting plasma glucose (mmol/l)	132	6.1 (0.77)	6.1 (1.03)	0.94
Body mass index (kg/m²)	129	27.9 (3.7)	26.9 (3.4)	0.12
History of hypertension (%)	128	46 (69.7)	36 (58.1)	0.17
History of diabetes (%)	128	7 (10.6)	8 (12.9)	0.68
Baseline lifestyle factors
Physical activity 2 or more times/week (%)	128	50 (73.5)	48 (80.0)	0.38
Current smokers (%)	130	1 (1.49)	4 (6.3)	0.15
Alcohol drinking at least once/week (%)	131	31 (45.5)	30 (47.6)	0.81
Fish intake at least twice/week (%)	130	42 (61.8)	33 (53.2)	0.32
Daily intake of vegetables (%)	132	47 (69.1)	41 (64.0)	0.53
*Baseline MRI measures
Total hippocampal volume, ml	132	7.4 (4.8–9.3)	7.2 (4.7–8.7)	0.18
Total intracranial volume, ml	132	1572.9 (1108.5–2032.7)	1545.4 (957.9–1955.9)	0.42
AD signature cortical thickness, mm	132	2.8 (2.4–3.1)	2.7 (2.4–3.1)	0.61
Total GM volume, ml	132	563.3 (450.7–669.7)	559.1 (420.7–695.8)	0.62
WML volume, ml	118	10.9 (12.5)	10.9 (14.3)	0.97
Cognitive measures
Baseline
NTB total score	132	− 0.12 (0.49)	− 0.009 (0.54)	0.22
Executive functioning	132	− 0.02 (0.55)	− 0.05 (0.60)	0.75
Processing speed	132	− 0.15 (0.80)	0.07 (0.75)	0.10
Memory	132	− 0.18 (0.58)	− 0.01 (0.60)	0.09
1 year follow-up
NTB total score	130	0.04 (0.61)	0.05 (0.58)	0.95
Executive functioning	129	0.05 (0.61)	− 0.05 (0.68)	0.33
Processing speed	130	− 0.04 (0.86)	0.07 (0.76)	0.39
Memory	130	0.09 (0.76)	0.11 (0.68)	0.87
2 year follow-up
NTB total score	122	0.09 (0.67)	0.09 (0.66)	0.98
Executive functioning	122	0.08 (0.65)	− 0.006 (0.70)	0.47
Processing speed	122	− 0.014 (0.94)	0.05 (0.85)	0.67
Memory	122	0.17 (0.77)	0.19 (0.78)	0.88

Values are means (SD) unless otherwise specified. Differences between the intervention and control groups were analyzed with chi-square and t tests as appropriate. Scores on the NTB total score, executive functioning, processing speed, memory, and abbreviated memory are mean values of Z scores of the cognitive tests included in each cognitive outcome. Higher scores indicate better performance. AD signature cortical thickness: cortical thickness in AD signature regions calculated as the average of cortical thickness in entorhinal, inferior temporal, middle temporal and fusiform regions as previously described [38]
GM gray matter, WML white matter lesions, NTB neuropsychological test battery
*MRI values are mean (minimum–maximum). MRI measures are based on longitudinal FreeSurfer analyses

Back to article page