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Table 2 Outcome measures

From: Early recognition and treatment of neuropsychiatric symptoms to improve quality of life in early Alzheimer’s disease: protocol of the BEAT-IT study

Outcome Measure Purpose Respondent Time of assessment
Demographic characteristics For example, age, education, sex, ethnicity, relation to caregiver Descriptive, covariate, moderator Patient and caregiver T0
Clinical characteristics For example, diagnosis, AD biomarkers, disease duration Descriptive, moderator Patient and caregiver T0*
 Disease severity CDR [57] Descriptive, moderator Patient T0*, T2
 Cognitive status MMSE [58] Descriptive, moderator Patient T0*, T2
 Cognitive functioning Standardized cognitive test battery [43]: RAVLT [59], VAT [60], DS [61], VF [62], LDST [63], SCWT [64], TMT [65] Descriptive, moderator Patient T0*
 Functional abilities A-IADL-Q [66] Descriptive, moderator Caregiver T0, T2
 Psychotropic medications Brown bag review [20] Descriptive, secondary outcome Caregiver T0, T1, T2
 Comorbidities CIRS-G [50] Descriptive Patient T0, T2
Quality of life patient QoL-AD [67] Primary outcome Patient and caregiver T0, T1, T2
Quality of life caregiver CarerQol-7D [53] Primary outcome Caregiver T0, T1, T2
Caregiver burden Perseverance time [68] Secondary outcome Caregiver T0, T1, T2
Caregiver competence managing NPS Additional NPI-Q item [69] Secondary outcome Caregiver T0, T1, T2
Cost-effectiveness EQ-5D-5 L [70], ICECAP-O [71] iMTA iVICQ [72], iMTA MCQ [73] Secondary outcome Patient Caregiver T0, T1, T2
NPS prevalence, severity, and distress NPI-Q [44] Secondary outcome Caregiver T0*, T1, T2
If NPI-Q frequency score ≥ 1 on:
 “Agitation,” “motor disturbances,” “irritability,” “disinhibition” Cohen-Mansfield Agitation Inventory [74] Secondary outcome Caregiver T0, T1, T2
 “Apathy” Apathy Evaluation Scale-I [75] Secondary outcome Caregiver T0, T1, T2
 “Depression,” “anxiety,” “elation” CSDD [76], RAID [77] Secondary outcome Caregiver T0, T1, T2
 “Hallucinations,” “delusions” BEHAVE-AD subscales psychosis, delusions [78] Secondary outcome Caregiver T0, T1, T2
 “Nighttime behaviors” Sleep Disorder Inventory [79] Secondary outcome Caregiver T0, T1, T2
  1. AD Alzheimer’s disease, CDR Clinical Dementia Rating, RAVLT Rey Auditory Verbal Learning Test, VAT Visual Association Test, DS Digit Span, VF Verbal Fluency (animals), LDST Letter Digit Substitution Test, SCWT Stroop Color Word Test, TMT Trail Making Test, MMSE Mini-Mental State Examination, A-IADL-Q Amsterdam Instrumental Activity of Daily Living Questionnaire, CIRS-G Cumulative Illness Rating Scale for Geriatrics, QoL-AD Quality of Life in Alzheimer’s Disease, iMTA iVIQ iMTA Valuation of Informal Care Questionnaire, iMTA MCQ iMTA Medical Costs Questionnaire, NPI-Q Neuropsychiatric Inventory Questionnaire, CSDD Cornell Scale for Depression in Dementia, RAID Rating Anxiety In Dementia, BEHAVE-AD Behavioral Pathology in Alzheimer’s Disease Rating Scale
  2. *Will be carried out during the diagnostic procedure at local hospitals