Altered microRNAs related to synaptic function as potential plasma biomarkers for Alzheimer’s disease

Table 3 Individual and signature miRNAs performance characteristics in predicting AD. Signature miRNAs performance characteristics in women and men

miRNA/signature	AUC	Sensitivity %	Specificity %	Youden Index J	P value
miR-92a-3p	0.697	47.37	92.86	0.402	0.0124
miR-181c-5p	0.773	70.18	85.71	0.559	< 0.0001
miR-210-3p	0.799	80.70	71.43	0.521	< 0.0001
miR-92a-3p/miR-210-3p	0.807	87.72	64.29	0.520	< 0.0001
miR-92a-3p/miR-181c-5p	0.787	84.21	71.43	0.556	0.0001
miR-181c-5p/miR-210-3p	0.853	84.21	78.57	0.628	< 0.0001
miR-92a-3p/miR-181c-5p/ miR-210-3p	0.855	92.86	71.43	0.644	< 0.0001
Women	0.815	90.24	71.43	0.617	0.0009
Men	0.938	75.0	100.0	0.750	< 0.0001

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