Fig. 1

Circulating miRNA levels at different stages of AD pathology compared with cognitively normal controls (a). Log2 transformed data were normalised versus the geometric mean of miR-191-5p and miR-484 levels. Statistical significance was evaluated by the Mann-Whitney U test followed by the Bonferroni correction for multiple comparisons. P values < 0.05 were considered statistically significant. b Receiver operating characteristic (ROC) curve analysis was performed to distinguish MCI (blue) and AD (red) cases from healthy controls. The area under the curve (AUC) is shown for each miRNA and stage