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Fig. 6 | Alzheimer's Research & Therapy

Fig. 6

From: Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice

Fig. 6

Levels of astrocytic and microglial markers in APP23 mice treated subchronically with saline, rHDL-rApoJ nanodiscs, or free rApoJ. a Expression of the reactive astrocyte marker GFAP in mouse APP23-brain homogenates after treatments. b Expression of microglial markers (CD68 and Iba-1) in mouse APP23-brain homogenates after treatments. Data are expressed as the mean ± SEM. N = 6–7/group. *p < 0.05. c Representative immunofluorescence images showing the localization of Iba1 and d representative immunofluorescence images showing the localization of CD68 around anti-Aβ (4G8)-positive deposits in brain slices from APP23 mice. e Representative immunofluorescence images showing the localization of CD68 with tomato lectin (TL, as a microglial marker) in brain slices from APP23 mice

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Alzheimer's Research & Therapy

ISSN: 1758-9193