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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice

Fig. 4

Neuronal loss in 15-month-old wt mice and APP23 mice treated subchronically with saline, rHDL-rApoJ nanodiscs or free rApoJ. a Representative images of NeuN-positive cells in CA1 region of the hippocampus and in poDG of APP23-treated mice and wt mice. b Quantification of NeuN-positive cells per square millimeter in the different studied regions (cortex, CA1, CA2/CA3, and poDG). Abbreviations: Ctx: Cortex; poDG: polymorphic layers of the dentate gyrus. Data are expressed as the mean ± SEM. N = 6–7/group. *p < 0.05 (comparison between WT and saline-APP23 groups) and p < 0.05 (comparison among APP23-treated groups)

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