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Table 4 Results of ROC analysis

From: Olfactory function is associated with cognitive performance: results from the population-based LIFE-Adult-Study

Cognitive test

 

Smell test score cut-off*

 
 

< 8

< 9

< 10

< 11

< 12

AUC (95% CI)

VF

Sensitivity

10.4

19.0

37.8

63.0

86.4

0.55

Specificity

92.1

84.8

69.3

44.4

16.1

(0.52–0.57)

Youden’s index

2.5

3.8

7.1

7.4

2.5

p < 0.001

WLL

Sensitivity

15.7

28.1

50.0

71.5

92.6

0.58

Specificity

89.4

79.9

63.3

39.8

13.5

(0.55–0.62)

Youden’s index

5.1

8.0

13.3

11.3

6.1

p < 0.001

WLR

Sensitivity

15.9

32.6

49.2

72.0

93.2

0.59

Specificity

89.1

79.8

62.5

39.2

13.2

(0.54–0.64)

Youden’s index

5.0

12.4

11.7

9.4

6.4

p = 0.001

TMT-A

Sensitivity

14.9

29.6

50.4

71.3

90.4

0.62

Specificity

92.2

85.3

69.8

44.5

16.2

(0.59–0.65)

Youden’s index

7.1

14.9

20.2

15.8

6.6

p < 0.001

TMT-B/A

Sensitivity

10.5

19.1

38.3

63.8

88.2

0.55

Specificity

92.1

84.8

69.3

44.4

16.2

(0.53–0.58)

Youden’s index

2.6

3.9

7.6

8.2

4.4

p < 0.001

  1. Youden’s index = sensitivity + specificity − 1. Highest Youden’s index is indicated in italics
  2. Sensitivity, specificity, and Youden’s index are given as percentages
  3. *Individuals having a smell test score below the cut-off are “test positive”, i.e., suspected of being cognitively impaired