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Table 5 Parameters in APP metabolism and synaptic proteins between genders of mice in different groups

From: Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation

  APP/PS1 APP/PS1+LF APP/PS1+HF
Male Female Male Female Male Female
BACE1 0.51 ± 0.20 0.49 ± 0.40 0.70 ± 0.30 0.62 ± 0.25 0.77 ± 0.20 0.80 ± 0.75
ADAM10 0.53 ± 0.20 0.47 ± 0.10 0.24 ± 0.10 0.36 ± 0.15 0.30 ± 0.20 0.23 ± 0.25
BACE2 0.43 ± 1.10 0.57 ± 0.75 0.44 ± 1.20 0.54 ± 0.90 0.37 ± 0.35 0.46 ± 0.50
SNAP-25 0.43 ± 0.10 0.57 ± 0.10 0.50 ± 0.95 0.41 ± 0.15 0.28 ± 0.30 0.37 ± 0.25
SYP 0.54 ± 0.15 0.46 ± 0.15 0.36 ± 0.10 0.46 ± 0.10 0.33 ± 0.05 0.29 ± 0.10
  1. Notice: APP/PS1, amyloid precursor protein/presenilin 1; LF, lower fluoride; HF, high fluoride. The values shown are means ± SD (n = 5) as determined by analysis of variance (ANOVA), followed by the least significant differences post hoc test