Skip to main content

Advertisement

Table 4 Biochemical parameters between genders of mice in different groups

From: Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation

Parameters APP/PS1 APP/PS1+LF APP/PS1+HF
Male Female Male Female Male Female
Fluoride contents
 Bones (ppm) 1.01 ± 0.11 1.00 ± 0.12 1.35 ± 0.05 1.29 ± 0.03 2.51 ± 0.06 2.57 ± 0.02
 Brains (ppm) 0.11 ± 0.01 0.11 ± 0.01 0.23 ± 0.02 0.26 ± 0.03 0.30 ± 0.01 0.29 ± 0.02
Morris water maze test
 Escape latency (s) 32.59 ± 3.34 34.06 ± 3.85 51.98 ± 3.76 54.65 ± 4.53 53.90 ± 2.34 51.98 ± 2.00
 Number of time of crossing the platform (N) 2.00 ± 0.71 2.20 ± 0.84 0.20 ± 4.50 0.40 ± 0.55 0.60 ± 0.89 0.20 ± 0.45
 Time remaining of the platform (s) 12.68 ± 1.27 12.89 ± 1.46 7.22 ± 0.96 7.32 ± 0.89 6.93 ± 1.05 7.45 ± 1.06
 Number of senile plaques (N) 10.80 ± 1.79 11.80 ± 2.17 33.80 ± 3.70 38.00 ± 2.45 43.20 ± 3.39 45.00 ± 3.87
Oxidative stress
 MDA (nmol/mg pr) 4.71 ± 0.15 4.83 ± 0.10 6.60 ± 0.40 7.00 ± 0.48 7.34 ± 0.22 7.60 ± 0.49
 SOD (U/mg pr) 121.29 ± 7.33 126.97 ± 5.67 80.31 ± 3.76 82.78 ± 4.59 59.18 ± 12.97 66.47 ± 9.45
 GSH-Px (kU/l) 186.80 ± 5.78 193.18 ± 4.87 122.44 ± 8.17 129.66 ± 7.63 71.08 ± 9.53 87.86 ± 16.54
  1. Notice: APP/PS1, amyloid precursor protein/presenilin 1; pr, protein. The values shown are means ± SD (n = 5), as determined by analysis of variance (ANOVA), followed by the least significant differences post hoc test