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Table 3 The MDA content and activities of SOD and GSH-Px in the brains of mice following 12 weeks of exposure to fluoride

From: Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation

Group n MDA (nmol/mg pr) SOD (U/mg pr) GSH-Px (kU/l)
WT 10 2.36 ± 0.12 206.85 ± 15.97 334.88 ± 5.53
WT+LF 10 2.60 ± 0.19 185.16 ± 16.01* 314.15 ± 12.5*
WT+HF 10 5.36 ± 0.29*# 101.32 ± 12.41*# 139.54 ± 11.28*#
APP/PS1 10 4.77 ± 0.13* 124.14 ± 7.71* 189.91 ± 5.43*
APP/PS1+LF 10 6.79 ± 0.43*^ 81.55 ± 4.43*^ 126.05 ± 8.87*^
APP/PS1+HF 10 7.47 ± 0.33*^& 62.82 ± 11.63*^& 79.92 ± 18.61*^&
  1. Notice: WT, wild-type; LF, low fluoride; HF, high fluoride; APP/PS1, amyloid precursor protein/presenilin 1; pr, protein. The values presented are *P < 0.05 vs control (WT); #P < 0.05 vs LF; ^P < 0.05 vs APP/PS1; &P < 0.05 vs APP/PS1+LF, as determined by analysis of variance (ANOVA), followed by the least significant differences post hoc test