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Table 3 The MDA content and activities of SOD and GSH-Px in the brains of mice following 12 weeks of exposure to fluoride

From: Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation

Group

n

MDA

(nmol/mg pr)

SOD

(U/mg pr)

GSH-Px

(kU/l)

WT

10

2.36 ± 0.12

206.85 ± 15.97

334.88 ± 5.53

WT+LF

10

2.60 ± 0.19

185.16 ± 16.01*

314.15 ± 12.5*

WT+HF

10

5.36 ± 0.29*#

101.32 ± 12.41*#

139.54 ± 11.28*#

APP/PS1

10

4.77 ± 0.13*

124.14 ± 7.71*

189.91 ± 5.43*

APP/PS1+LF

10

6.79 ± 0.43*^

81.55 ± 4.43*^

126.05 ± 8.87*^

APP/PS1+HF

10

7.47 ± 0.33*^&

62.82 ± 11.63*^&

79.92 ± 18.61*^&

  1. Notice: WT, wild-type; LF, low fluoride; HF, high fluoride; APP/PS1, amyloid precursor protein/presenilin 1; pr, protein. The values presented are *P < 0.05 vs control (WT); #P < 0.05 vs LF; ^P < 0.05 vs APP/PS1; &P < 0.05 vs APP/PS1+LF, as determined by analysis of variance (ANOVA), followed by the least significant differences post hoc test