TY - JOUR AU - Cao, Kun AU - Xiang, Jie AU - Dong, Yang-Ting AU - Xu, Yi AU - Li, Yi AU - Song, Hui AU - Zeng, Xiao-Xiao AU - Ran, Long-Yan AU - Hong, Wei AU - Guan, Zhi-Zhong PY - 2019 DA - 2019/04/22 TI - Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation JO - Alzheimer's Research & Therapy SP - 35 VL - 11 IS - 1 AB - Alzheimer’s disease (AD) is responsible for 60–70% of all cases of dementia. On the other hand, the tap water consumed by hundreds of millions of people has been fluoridated to prevent tooth decay. However, little is known about the influence of fluoride on the expression of APP and subsequent changes in learning and memory and neuropathological injury. Our aim here was to determine whether exposure to fluoride aggravates the neuropathological lesions in mice carrying the amyloid precursor protein (APP)/presenilin1 (PS1) double mutation. SN - 1758-9193 UR - https://doi.org/10.1186/s13195-019-0490-3 DO - 10.1186/s13195-019-0490-3 ID - Cao2019 ER -