TY - JOUR AU - Wirth, Miranka AU - Schwarz, Claudia AU - Benson, Gloria AU - Horn, Nora AU - Buchert, Ralph AU - Lange, Catharina AU - Köbe, Theresa AU - Hetzer, Stefan AU - Maglione, Marta AU - Michael, Eva AU - Märschenz, Stefanie AU - Mai, Knut AU - Kopp, Ute AU - Schmitz, Dietmar AU - Grittner, Ulrike AU - Sigrist, Stephan J. AU - Stekovic, Slaven AU - Madeo, Frank AU - Flöel, Agnes PY - 2019 DA - 2019/05/01 TI - Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)—study protocol for a randomized controlled trial JO - Alzheimer's Research & Therapy SP - 36 VL - 11 IS - 1 AB - Given the global increase in the aging population and age-related diseases, the promotion of healthy aging is one of the most crucial public health issues. This trial aims to contribute to the establishment of effective approaches to promote cognitive and brain health in older individuals with subjective cognitive decline (SCD). Presence of SCD is known to increase the risk of objective cognitive decline and progression to dementia due to Alzheimer’s disease. Therefore, it is our primary goal to determine whether spermidine supplementation has a positive impact on memory performance in this at-risk group, as compared with placebo. The secondary goal is to examine the effects of spermidine intake on other neuropsychological, behavioral, and physiological parameters. SN - 1758-9193 UR - https://doi.org/10.1186/s13195-019-0484-1 DO - 10.1186/s13195-019-0484-1 ID - Wirth2019 ER -