|
Cohort
|
SN
|
SP
|
PPV
|
NPV
|
Accuracy
|
Bal. Acc.
|
|---|
|
All (n = 429)
|
|
Without tool
|
0.67
|
0.79
|
0.43
|
0.91
|
0.76
|
0.73
|
|
With tool
|
0.60
|
0.81
|
0.43
|
0.89
|
0.77
|
0.70
|
|
DSI
|
0.63
|
0.83
|
0.47
|
0.90
|
0.79
|
0.73
|
|
Excl. non-AD dementia (n = 405)
|
|
Without tool
|
0.67
|
0.79
|
0.35
|
0.93
|
0.77
|
0.73
|
|
With tool
|
0.62
|
0.81
|
0.36
|
0.92
|
0.78
|
0.71
|
|
DSI
|
0.63
|
0.83
|
0.39
|
0.93
|
0.80
|
0.73
|
|
SCD (n = 230)
|
|
Without tool
|
0.67
|
0.87
|
0.34
|
0.96
|
0.85
|
0.77
|
|
With tool
|
0.67
|
0.88
|
0.35
|
0.96
|
0.86
|
0.77
|
|
DSI*
|
0.33
|
0.96
|
0.47
|
0.93
|
0.90
|
0.65
|
|
MCI (n = 199)
|
|
Without tool
|
0.67
|
0.66
|
0.48
|
0.81
|
0.66
|
0.66
|
|
With tool
|
0.57
|
0.71
|
0.48
|
0.78
|
0.67
|
0.64
|
|
DSI
|
0.73
|
0.62
|
0.47
|
0.83
|
0.65
|
0.67
|
|
DSI ≤ 0.2 or DSI ≥ 0.8 (n = 203)
|
|
Without tool
|
0.67
|
0.92
|
0.44
|
0.97
|
0.90
|
0.79
|
|
With tool
|
0.61
|
0.96
|
0.58
|
0.96
|
0.93
|
0.78
|
|
DSI
|
0.78
|
0.98
|
0.78
|
0.98
|
0.96*
|
0.88
|
- Abbreviations: Prog conversion of SCD to MCI, AD or another type of dementia, and MCI to AD or another type of dementia; SN sensitivity; SP specificity; PPV positive predictive value; NPV negative predictive value; Bal.Acc. balanced accuracy; DSI disease state index; SCD subjective cognitive decline; MCI mild cognitive impairment
- **Significant difference between without tool and DSI classification accuracy, p = 0.012
- *Results from different cutoff values are available in Additional file 1: Table S8
