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Table 4 Performance to predict progression for clinicians without and with the PredictND tool, and the DSI classification alone

From: Impact of a clinical decision support tool on prediction of progression in early-stage dementia: a prospective validation study

Cohort SN SP PPV NPV Accuracy Bal. Acc.
All (n = 429)
 Without tool 0.67 0.79 0.43 0.91 0.76 0.73
 With tool 0.60 0.81 0.43 0.89 0.77 0.70
 DSI 0.63 0.83 0.47 0.90 0.79 0.73
Excl. non-AD dementia (n = 405)
 Without tool 0.67 0.79 0.35 0.93 0.77 0.73
 With tool 0.62 0.81 0.36 0.92 0.78 0.71
 DSI 0.63 0.83 0.39 0.93 0.80 0.73
SCD (n = 230)
 Without tool 0.67 0.87 0.34 0.96 0.85 0.77
 With tool 0.67 0.88 0.35 0.96 0.86 0.77
 DSI* 0.33 0.96 0.47 0.93 0.90 0.65
MCI (n = 199)
 Without tool 0.67 0.66 0.48 0.81 0.66 0.66
 With tool 0.57 0.71 0.48 0.78 0.67 0.64
 DSI 0.73 0.62 0.47 0.83 0.65 0.67
DSI ≤ 0.2 or DSI ≥ 0.8 (n = 203)
 Without tool 0.67 0.92 0.44 0.97 0.90 0.79
 With tool 0.61 0.96 0.58 0.96 0.93 0.78
 DSI 0.78 0.98 0.78 0.98 0.96* 0.88
  1. Abbreviations: Prog conversion of SCD to MCI, AD or another type of dementia, and MCI to AD or another type of dementia; SN sensitivity; SP specificity; PPV positive predictive value; NPV negative predictive value; Bal.Acc. balanced accuracy; DSI disease state index; SCD subjective cognitive decline; MCI mild cognitive impairment
  2. **Significant difference between without tool and DSI classification accuracy, p = 0.012
  3. *Results from different cutoff values are available in Additional file 1: Table S8