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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Impact of a clinical decision support tool on prediction of progression in early-stage dementia: a prospective validation study

Fig. 2

Disease state fingerprints from the PredictND tool. a A 46-year-old male with a family history of early-onset dementia and 1 year of word-finding problems, loss of initiative, and subjective complaints of affected memory and sleep. Aβ42, 1059 ng/L; total tau, 201 ng/L; and P-tau, 43 ng/L. Diagnosed with SCD at baseline. The DSI value (0.06) predicted a stable condition and increased the clinician’s confidence from a VAS score of 55% to 80% in the prediction of stable SCD. After the 18-month follow-up, the diagnosis was still stable SCD. b A 76-year-old female with mild forgetfulness for words and names during the last 2 years. Normal daily function. MMSE, 30; CERAD learning, 21/30; and CERAD recall, 1/10. Diagnosed with MCI at baseline. The DSI value (0.51) did not indicate a clear stable or progressive condition. The clinician without tool predicted the follow-up diagnosis to be stable MCI, whereas the clinician with tool predicted the patient to progress to AD dementia. The diagnosis at 24-month follow-up was MCI, but after the end of the project at a 3-year follow-up visit, the patient was diagnosed with AD dementia. c A 74-year-old male with memory problems for events and names, loss of initiative, and orientation. Aβ42, 358 ng/L; total tau, 370 ng/L; and P-tau, 50 ng/L. Diagnosed with amnestic MCI at baseline. The DSI value (0.78) predicted progression and increased the clinician’s confidence in the prediction of progression to dementia by 30% on the VAS scale. After the 12-month follow-up, the patient had progressed to AD dementia

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