Skip to main content

Table 3 Characteristics associated with death and institutionalization during the follow-up

From: CSF level of β-amyloid peptide predicts mortality in Alzheimer’s disease

Characteristics

Death

Institutionalization

No

Yes

 

No

Yes

 

(N = 264)

(N = 57)

P value

(N = 250)

(N = 71)

P value

Age, year, mean (SD)

70.4 (8.2)

73.8 (9.3)

0.001

71.0 (8.2)

70.9 (9.5)

0.89

Women, n (%)

172 (65.2)

28 (49.1)

0.02

159 (63.6)

41 (57.8)

0.39

MMSE, mean (SD)

20.7 (5.6)

18.3 (6.6)

0.008

20.7 (5.9)

18.9 (5.5)

0.01

Level of education, n (%)

 Low

82 (33.7)

24 (44.4)

 

86 (37.7)

20 (29.0)

 

 Intermediate

92 (37.9)

18 (33.3)

 

77 (33.8)

33 (47.8)

 

 High

69 (28.4)

12 (22.2)

0.32

65 (28.5)

16 (23.2)

0.10

APOE ε4, n (%)

 0

100 (37.9)

25 (43.9)

 

99 (39.6)

26 (36.6)

 

 1

117 (44.3)

24 (42.1)

 

106 (42.4)

35 (49.3)

 

 2

47 (17.8)

8 (14.0)

0.65

45 (18.0)

10 (14.1)

0.54

CSF biomarkers, pg/mL, mean (SD)

 Aβ42

505.9 (127.8)

381.6 (118.7)

< 0.001

496.6 (135.9)

438.7 (121.3)

0.001

 Aβ40b

13,284 (5362)

13,474 (6697)

0.51

13,195 (5351)

14,165 (6312)

0.36

 Ratio Aβ42/40b

0.047 (0.022)

0.039 (0.013)

0.08

0.046 (0.019)

0.049 (0.038)

0.56

 Tau

680.9 (273.0)

703.6 (296.2)

0.69

685.4 (280.0)

683.2 (267.5)

0.93

 p-Tau 181

102.5 (41.0)

102.9 (28.3)

0.88

102.5 (39.5)

102.8 (37.4)

0.94

  1. aLow: primary school or less, intermediate: secondary to high school, high: baccalaureate or university degree
  2. bCSF Aβ40 was available for 214 patients