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Table 1 Point estimates of odds ratios (OR) from ordinal logistic regression of the impact of the coprevalence of five brain lesions on cognitive performance within 2 years of death

From: Concepts for brain aging: resistance, resilience, reserve, and compensation

Lesion co-morbidity index

OR for the Nun Study (n = 334)

OR for the Honolulu Asia Aging Study (n = 774)

0

1.0 (reference)

1.0 (reference)

0.4–0.8

2.8

2.4

1.0–1.8

5.0

4.6

2.0–2.4

23.1

16.3

2.6–4.4

99.1

37.6

  1. Severity of each of the five brain lesions (Braak stage for neurofibrillary degeneration, cerebral cortical Lewy body disease, cerebral cortical microinfarcts, hippocampal sclerosis, low brain weight) was scored as none/mild (0), moderate (0.4), or severe (1.0) by established criteria, and the lesion co-morbidity index was calculated as the sum of scores for each of the five lesions [1]
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Alzheimer's Research & Therapy

ISSN: 1758-9193