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Table 2 Centiloid cut-off against CSF biomarkers. Derivation was done by maximization of YI or OPA. Other statistics for this cut-off have been also derived: PPA, NPA and AUC. 95% CI are shown between brackets. All participants’ information was used to derive these cut-offs

From: Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers

Biomarker   YI’s derived cut-offs OPA’s derived cut-offs
AUC CL cut-off YIa OPA PPA NPA CL cut-off YI OPAa PPA NPA
42 0.874 [0.840–0.903] 12.1 0.659 [0.594–0.721] 0.831 [0.798–0.861] 0.852 [0.809–0.892] 0.806 [0.753–0.851] 11.6 0.659 [0.593–0.720] 0.831 [0.798–0.861] 0.855 [0.812–0.895] 0.804 [0.750–0.849]
pTau/Aβ42 0.974 [0.956–0.9985] 28.8 0.886 [0.842–0.922] 0.943 [0.921–0.961] 0.941 [0.904–0.964] 0.945 [0.915–0.970] 28.8 0.886 [0.842–0.922] 0.943 [0.921–0.961] 0.941 [0.904–0.964] 0.945 [0.915–0.970]
tTau/Aβ42 0.961 [0.940–0.975] 29.7 0.863 [0.818–0.905] 0.931 [0.908–0.952] 0.948 [0.912–0.970] 0.915 [0.882–0.946] 30.1 0.863 [0.818–0.905] 0.931 [0.908–0.952] 0.948 [0.911–0.970] 0.915 [0.882–0.947]
pTau 0.833 [0.793–0.869] 29.3 0.689 [0.629–0.745] 0.822 [0.787–0.853] 0.755 [0.704–0.798] 0.934 [0.898–0.966] 18.7 0.680 [0.610–0.732] 0.823 [0.787–0.852] 0.773 [0.726–0.816] 0.907 [0.856–0.939]
tTau 0.774 [0.727–0.814] 28.6 0.573 [0.505–0.640] 0.781 [0.747–0.815] 0.745 [0.693–0.792] 0.828 [0.779–0.875] 26.7 0.573 [0.502–0.639] 0.781 [0.745–0.815] 0.748 [0.697–0.795] 0.825 [0.773–0.870]
  1. aShows the statistic was used to derive each cut-off
  2. pTau phosphorylated tau, tTau total tau, CL Centiloids, OPA overall percentage agreement (“accuracy”), YI Youden’s J Index, PPA positive percentage agreement (“sensitivity”), NPA negative percentage agreement (“specificity”), AUC area under the curve