Alzheimer's Research & Therapy

Table 2 Centiloid cut-off against CSF biomarkers. Derivation was done by maximization of YI or OPA. Other statistics for this cut-off have been also derived: PPA, NPA and AUC. 95% CI are shown between brackets. All participants’ information was used to derive these cut-offs

From: Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers

Biomarker		YI’s derived cut-offs					OPA’s derived cut-offs
Biomarker	AUC	CL cut-off	YI^a	OPA	PPA	NPA	CL cut-off	YI	OPA^a	PPA	NPA
Aβ₄₂	0.874 [0.840–0.903]	12.1	0.659 [0.594–0.721]	0.831 [0.798–0.861]	0.852 [0.809–0.892]	0.806 [0.753–0.851]	11.6	0.659 [0.593–0.720]	0.831 [0.798–0.861]	0.855 [0.812–0.895]	0.804 [0.750–0.849]
pTau/Aβ₄₂	0.974 [0.956–0.9985]	28.8	0.886 [0.842–0.922]	0.943 [0.921–0.961]	0.941 [0.904–0.964]	0.945 [0.915–0.970]	28.8	0.886 [0.842–0.922]	0.943 [0.921–0.961]	0.941 [0.904–0.964]	0.945 [0.915–0.970]
tTau/Aβ₄₂	0.961 [0.940–0.975]	29.7	0.863 [0.818–0.905]	0.931 [0.908–0.952]	0.948 [0.912–0.970]	0.915 [0.882–0.946]	30.1	0.863 [0.818–0.905]	0.931 [0.908–0.952]	0.948 [0.911–0.970]	0.915 [0.882–0.947]
pTau	0.833 [0.793–0.869]	29.3	0.689 [0.629–0.745]	0.822 [0.787–0.853]	0.755 [0.704–0.798]	0.934 [0.898–0.966]	18.7	0.680 [0.610–0.732]	0.823 [0.787–0.852]	0.773 [0.726–0.816]	0.907 [0.856–0.939]
tTau	0.774 [0.727–0.814]	28.6	0.573 [0.505–0.640]	0.781 [0.747–0.815]	0.745 [0.693–0.792]	0.828 [0.779–0.875]	26.7	0.573 [0.502–0.639]	0.781 [0.745–0.815]	0.748 [0.697–0.795]	0.825 [0.773–0.870]

^aShows the statistic was used to derive each cut-off
pTau phosphorylated tau, tTau total tau, CL Centiloids, OPA overall percentage agreement (“accuracy”), YI Youden’s J Index, PPA positive percentage agreement (“sensitivity”), NPA negative percentage agreement (“specificity”), AUC area under the curve

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