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Table 2 Concentrations of biomarkers for each group and group comparisons

From: Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer’s disease

  DS sAD Controls ANCOVA Post hoc
40 312.00 (150.24–555.00) 160.80 (43.60–420.00) 144.40 (26.88–355.60) F(2,79) = 24.28, p < 0.001, η2 = 0.38 DS vs sAD p < 0.001
DS vs controls p < 0.001
sAD vs controls p = 0.506
42 24.48 (14.92–50.40) 13.32 (4.28–18.84) 14.76 (2.00–45.62) F(2,79) = 20.36, p < 0.001, η2 = 0.34 DS vs sAD p < 0.001
DS vs controls p < 0.001
sAD vs controls p = 0.710
42/Aβ40 0.09 (0.05–0.13) 0.08 (0.04–0.11) 0.10 (0.07–0.17) F(2,79) = 15.43, p < 0.001, η2 = 0.28 DS vs sAD p = 1.000
DS vs controls p < 0.001
sAD vs controls p < 0.001
42/t-tau 20.60 (1.17–93.33) 10.23 (0.77–52.00) 10.59 (1.14–82.25) F(2,79) = 2.30, p = 0.107, η2 = 0.06 N/A
T-tau 1.45 (0.18–12.72) 1.00 (0.33–24.48) 1.49 (0.16–10.24) F(2,79) = 0.64, p = 0.529, η2 = 0.02 N/A
IL1βa 2.35 (0.27–47.20) 0.18 (0.02–5.45) 0.09 (0.00–1.25) F(2,41) = 13.84, p < 0.001, η2 = 0.40 DS vs sAD p = 0.002
DS vs controls p < 0.001
sAD vs controls p = 1.000
IL10b 1.34 (0.36–93.20) 0.75 (0.27–8.76) 0.87 (0.27–4.48) F(2,76) = 2.38, p = 0.100, η2 = 0.06 N/A
IL6b 2.12 (0.36–1024.00) 1.45 (0.50–9.56) 1.54 (0.07–8.70) F(2,76) = 2.54, p = 0.086, η2 = 0.06 N/A
TNFαb 2.76 (1.25–328.80) 2.37 (1.36–20.44) 1.97 (0.56–10.50) F(2,76) = 2.42, p = 0.096, η2 = 0.06 N/A
  1. Concentrations (pg/ml) given are median (range). ANCOVA performed on log-transformed values and including age, sex, and the presence of an APOE ε4 allele as covariates
  2. aOne plate failed (14 DS, 11 sAD, 13 controls)
  3. bThree samples failed (2 DS and 1 sAD)