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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer’s disease

Fig. 3

a The approximate location of rs8019381 and splicing patterns at the SS#5 of the NRXN3 gene. The number of potential variants for the splicing site is 30. Exon 24 is the last exon of the gene that codes for the transmembrane region, cytoplasmic domain, and contains 3′UTR. Because any exon 23 isoforms include in-frame stop codons (depicted as asterisks), if it is inserted, soluble α-NRXN3 and β-NRXN3 can be produced from this gene. b The three major transmembrane isoforms and one major soluble isoform are investigated in the prefrontal cortex in individuals with AD (n = 58) and controls (n = 48). Each probe for the RT-PCR was designed across both exons. c Expression levels of total NRXN3 mRNA in the middle frontal gyrus (MTG), middle temporal gyrus (MTG), and hippocampus (HIP)

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