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Table 1 Demographics and clinical features of the case series at entry and follow-up

From: Brain glucose metabolism in Lewy body dementia: implications for diagnostic criteria

Clinical classification at entry Possible DLB Probable DLB Atypical parkinsonism MCI Other dementias
N 10 34 5 15 8
Gender (M/F) 4/6 21/13 3/2 10/5 4/4
Age at PET scan (years) 70.40 ± 7.93 (59–81) 74.56 ± 7.94 (48–93) 68.20 ± 8.08 (57–77) 68.80 ± 5.47 (58–78) 75.00 ± 6.14 (68–88)
MMSE score at entry 19.11 ± 3.68 (14–24) 17.87 ± 5.21 (7.70–26.70) 18.76 ± 2–20 (15.60–20.30) 22.20 ± 2.86 (18.9–27) 13.36 ± 2.06 (10–15.3)
Disease duration at entry (years) 3.68 ± 2.75 (1.00–10.75) 2.38 ± 1.53 (0.20–6.00) 2.30 ± 2.09 (0.30–5.50) 1.23 ± 0.83 (0.33–2.90) 3.59 ± 2.07 (0.20–7.00)
Time of follow-up (years) 2.70 ± 1.63 (0.34–4.36) 3.09 ± 1.46 (0.77–6.04) 3.71 ± 1.29 (2.92–5.20) 2.89 ± 0.32 (0.78–4.93) 1.41 ± 0.39 (1.16–1.86)
Visual hallucinations (%) 30% 53% 40% 53% 63%
Cognitive fluctuations (%) 0% 35% 20% 27% 38%
Parkinsonism (%) 100% 94% 100% 67% 75%
aClinical classification at follow-up Probable DLB Probable DLB Probable DLB Probable DLB Probable DLB
Visual hallucinations (%) 90% 74% 80% 67% 88%
Cognitive fluctuations (%) 70% 82% 60% 53% 63%
Parkinsonism (%) 100% 100% 100% 80% 75%
RBD (%) 40% 62% 20% 40% 38%
Neuroleptic sensitivity (%) 10% 6% 0% 0% 0%
Available DATSCAN (N) 3 out of 10 (positive) 7 out of 34 (positive) 3 out of 5 (positive) 1 out of 15 (positive) 0 out of 8
  1. aClinical Research Criteria for probable DLB diagnosis according to McKeith et al. 2005
  2. Data are reported as mean ± standard deviation (range)
  3. Abbreviations: DLB dementia with Lewy bodies, MCI mild cognitive impairment