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Table 1 Participant demographics and serum NfL concentration. For variables with missing data points, the number of observations is shown underneath the group average value (e.g. n = x). EYO estimated years to/from onset, MMSE Mini-Mental State Examination, CDR Clinical Dementia Rating Scale, SOB sum of boxes

From: Longitudinal measurement of serum neurofilament light in presymptomatic familial Alzheimer’s disease

  Non-carriers
N = 15
Presymptomatic
N = 25
Symptomatic
N = 21
Gender (female/male) 11/4 13/12 7/14
Age (mean, SD) 39.7 (9.1) 36.2 (5.8) 47.4 (9.3)
EYO (years) (mean, SD) n/a − 9.25 (6.21) 3.09 (3.53)
MMSE (median, IQR) 30 (30–30) 30 (29–30) 23 (19.5–26.5)
(n = 20)
CDR Global (median, IQR) 0 (0–0) 0 (0–0) 0.5 (0.5–1.0)
(n = 18)
CDR SOB (median, IQR) 0 (0–0) 0 (0–0) 3.25 (1.5–4.5)
(n = 18)
Baseline NfL (pg/mL)
(mean, SD)
10.34 (7.62) 12.83 (6.71) 22.60 (12.28)
Annualised rate of change in NfL (pg/mL/years) (mean, SD)* 0.51 (1.54)
(n = 9)
0.67 (3.72)
(n = 17)
3.52 (3.72)
(n = 5)
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