From: Longitudinal measurement of serum neurofilament light in presymptomatic familial Alzheimer’s disease
Non-carriers N = 15 | Presymptomatic N = 25 | Symptomatic N = 21 | |
---|---|---|---|
Gender (female/male) | 11/4 | 13/12 | 7/14 |
Age (mean, SD) | 39.7 (9.1) | 36.2 (5.8) | 47.4 (9.3) |
EYO (years) (mean, SD) | n/a | − 9.25 (6.21) | 3.09 (3.53) |
MMSE (median, IQR) | 30 (30–30) | 30 (29–30) | 23 (19.5–26.5) (n = 20) |
CDR Global (median, IQR) | 0 (0–0) | 0 (0–0) | 0.5 (0.5–1.0) (n = 18) |
CDR SOB (median, IQR) | 0 (0–0) | 0 (0–0) | 3.25 (1.5–4.5) (n = 18) |
Baseline NfL (pg/mL) (mean, SD) | 10.34 (7.62) | 12.83 (6.71) | 22.60 (12.28) |
Annualised rate of change in NfL (pg/mL/years) (mean, SD)* | 0.51 (1.54) (n = 9) | 0.67 (3.72) (n = 17) | 3.52 (3.72) (n = 5) |