Fig. 5

¹⁸F-flortaucipir in C9ORF72, GRN mutation carriers and svPPA. a Five C9ORF72 carriers scanned with ¹⁸F-flortaucipir and corresponding single-subject w-score maps. Patient 1 is 71 years old, MMSE 26, CDR-SB 1, PiB negative. Patient 2 is 67 years old, MMSE 22, CDR-SB 8, Aβ status unavailable. Patient 3 is 48 years old, MMSE 26, CDR-SB 7, PiB negative. Patient 4 is 54 years old, MMSE 26, CDR-SB 7, PiB negative. Patient 5 is 71 years old, MMSE 26, CDR-SB 0.5 PiB negative. b GRN mutation carrier with corresponding structural MRI and single-subject w-score map, 55 years old, MMSE 21, CDR-SB 4.5, PiB positive. Structural MRI demonstrates asymmetrical left hemispheric atrophy corresponding to location of tracer uptake. c Two svPPA patients with corresponding single-subject w-score maps. Patient 1 is a 59-year-old female, MMSE 28, CDR-SB 3.5, PiB negative. Patient 2 is a 71-year-old male, MMSE 25, CDR-SB 3.5, PiB negative. d ¹⁸F-flortaucipir SUVR values for patients with C9ORF72 and GRN mutations (C9 + P), for each pre-specified region of interest. e ¹⁸F-flortaucipir SUVR values for patients with svPPA for each pre-specified region of interest; horizontal bar denotes mean. L, left; NC, normal control; FTP, ¹⁸F-flortaucipir; *p ≤ 0.05