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Table 1 Demographics and clinical characteristics

From: Data-driven prognostic features of cognitive trajectories in patients with amnestic mild cognitive impairments

 

Total (n = 278)

Stable (n = 142)

Slow decliner (n = 105)

Fast decliner (n = 31)

p valuea

Age, years

70.9 ± 7.12

70.0 ± 6.97

71.1 ± 7.29

74.5 ± 6.17b

0.006

Gender, female (%)

166 (59.7)

83 (58.5)

62 (59.0)

21 (67.7)

0.624

Education, year

11.5 ± 4.90

11.5 ± 4.99

11.4 ± 4.91

11.9 ± 4.56

0.896

Vascular risk factor (%)

 Hypertension

109/244(44.6%)

52/116 (44.9%)

43/97 (44.4%)

14/31 (45.2%)

0.891

 Diabetes mellitus

76/244 (31.1%)

34/116 (29.3%)

32/97 (33.0%)

10/31 (32.3%)

0.475

 Hyperlipidemia

64/244 (26.2%)

33/116 (28.5%)

21/97 (21.6%)

10/31 (32.3%)

0.508

 Cardiac disease

50/244 (20.5%)

21/116 (18.1%)

23/97 (23.7%)

6/31 (19.3%)

0.551

 Previous stroke

8/243 (3.3%)

6/115 (5.2%)

2/97 (2.1%)

0/31 (0%)

0.374

APOE genotype (%)

 APOE e2 carrier

21 (8.4)

15 (11.6)

5 (5.5)

1 (3.6)

0.427

 APOE e4 carrier

93 (37.3)

37 (28.7)

44 (48.4)b

11 (39.2)

0.025

Conversion to dementia (%)

124 (44.6)

10 (7.0)

83 (79.0)

31 (100)

< 0.0001

Reversion to normal (%)

31 (11.2)

31 (21.8)

0 (0)

0 (0)

< 0.0001

  1. APOE apolipoprotein E
  2. aAnalysis of covariance (ANCOVA) or chi-square test was performed
  3. bSignificant difference compared with the stable group, defined as p < 0.05 from post-hoc analysis using Bonferroni’s correction