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Fig. 8 | Alzheimer's Research & Therapy

Fig. 8

From: CHIMERA repetitive mild traumatic brain injury induces chronic behavioural and neuropathological phenotypes in wild-type and APP/PS1 mice

Fig. 8

Aβ analyses. Brain homogenates from mice harvested at 8 M post-TBI were serially extracted in carbonate and then guanidine HCl (GuHCl) buffer. a The concentration of Aβ40 and Aβ42 in the GuHCl-soluble fraction is plotted. b The concentration of Aβ40 and Aβ42 in the carbonate-soluble fraction is plotted. c Using an Octet RED system with streptavidin biosensors, the levels of aducanumab-binding high-molecular-weight oligomeric and soluble fibril fragment forms of Aβ and the total level of Poly8029-binding Aβ were assayed. Human IgG1 served as an isotype control for aducanumab. Data are plotted as mean ± SE with an overlaid scatterplot of individual animals

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