Fig. 3

Elevated plus maze task performance. From D7 to 8 M post-TBI, mice were tested in the EPM. The difference between the time spent in the closed arms and the open arms are plotted and expressed as mean ± SE. A greater value indicates more time spent in the closed arms and less time in the open arms, suggesting greater anxiety. A smaller value indicates that the mice spent relatively more time in the open arms and less time in the closed arms, suggesting greater risk-taking behaviour. n = 6–13 per genotype per injury per time point