Model 1 (Direct) | Model 2 (Age-corrected) | Model 3 (Hypertension-corrected) | ||||
---|---|---|---|---|---|---|
Effect size (95% CI) | p | Effect size (95% CI) | p | Effect size (95% CI) | p | |
CAIDE-I | 0.11 (0.03 to 0.19) | 0.017 | 0.01 (−0.07 to 0.09) | 0.423 | 0.01 (−0.08 to 0.09) | 0.444 |
Age | 0.22 (0.13 to 0.29) | < 0.001 | – | – | 0.18 (0.09 to 0.26) | < 0.001 |
Hypertension | 0.14 (0.05 to 0.22) | < 0.001 | 0.09 (0.00 to 0.17) | 0.017 | – | – |
Hypercholesterolemia | 0.09 (0.00 to 0.17) | 0.042 | 0.05 (−0.04 to 0.14) | 0.207 | 0.07 (−0.02 to 0.15) | 0.051 |
BMI | 0.08 (−0.00 to 0.16) | 0.053 | 0.06 (−0.02 to 0.14) | 0.207 | 0.03 (−0.05 to 0.11) | 0.249 |
Sex (Men) | −0.01 (−0.09 to 0.08) | 0.411 | −0.01 (−0.10 to 0.07) | 0.423 | −0.03 (−0.11 to 0.05) | 0.246 |
Education | −0.04 (−0.13 to 0.04) | 0.192 | −0.01 (−0.09 to 0.08) | 0.423 | −0.02 (−0.11 to 0.06) | 0.313 |
Physical exercise | −0.04 (−0.13 to 0.04) | 0.192 | −0.05 (−0.14 to 0.03) | 0.207 | −0.02 (−0.10 to 0.07) | 0.352 |
Maternal family history of AD* | 0.12 (−0.02 to 0.17) | 0.077 | 0.12 (0.03 to 0.21) | 0.024 | 0.08 (−0.01 to 0.18) | 0.040 |
APOE-ε2/ε3* | −0.13 (−0.24 to -0.01) | 0.042 | −0.08 (−0.20 to 0.04) | 0.2077 | −0.10 (−0.21 to 0.02) | 0.054 |