Table 3 Significantly AD-associated genes from gene-based analyses
From: Genome-wide analysis of genetic predisposition to Alzheimer’s disease and related sex disparities
Gene | Chromosomal region | Start | End | Number of SNPs | Plan 1 (males and females) | Plan 2 (only males) | Plan 3 (only females) | |||
|---|---|---|---|---|---|---|---|---|---|---|
χ 2 | p value | χ 2 | p value | χ 2 | p value | |||||
CEACAM16 | 19q13.32 | 44,699,150 | 44,710,714 | 83 | 330.47 | 7.52E–06 | NS | NS | NS | NS |
BCL3 | 19q13.32 | 44,748,720 | 44,760,044 | 63 | 274.81 | 3.95E–06 | NS | NS | 254.31 | 5.44E–06 |
MIR8085 | 19q13.32 | 44,758,656 | 44,758,721 | 52 | 235.68 | 8.72E–06 | NS | NS | NS | NS |
CBLC | 19q13.32 | 44,777,868 | 44,800,646 | 62 | 419.91 | 2.02E–10 | NS | NS | NS | NS |
BCAM | 19q13.32 | 44,809,058 | 44,821,421 | 51 | 455.39 | 1.07E–10 | NS | NS | 298.41 | 5.00E–07 |
PVRL2 | 19q13.32 | 44,846,135 | 44,889,228 | 90 | 3861.00 | 4.74E–72 | 1357.12 | 4.52E–25 | 2304.33 | 7.11E–43 |
TOMM40 | 19q13.32 | 44,891,219 | 44,903,689 | 73 | 3664.74 | 9.12E–86 | 1288.14 | 8.98E–30 | 2171.92 | 1.26E–50 |
APOE | 19q13.32 | 44,905,781 | 44,909,393 | 70 | 3590.18 | 4.32E–85 | 1262.22 | 1.09E–29 | 2121.68 | 3.58E–50 |
APOC1 | 19q13.32 | 44,914,663 | 44,919,349 | 67 | 3482.70 | 4.76E–87 | 1230.83 | 1.63E–30 | 2049.54 | 4.25E–51 |
APOC1P1 | 19q13.32 | 44,926,802 | 44,931,386 | 57 | 3427.13 | 6.60E–93 | 1209.89 | 1.01E–32 | 2008.34 | 2.00E–54 |
APOC4 | 19q13.32 | 44,942,237 | 44,945,496 | 46 | 3063.64 | 5.63E–89 | 1058.60 | 7.90E–31 | 1792.11 | 3.94E–52 |
APOC4–APOC2 | 19q13.32 | 44,942,237 | 44,949,565 | 46 | 3063.64 | 5.63E–89 | 1058.60 | 7.90E–31 | 1792.11 | 3.94E–52 |
APOC2 | 19q13.32 | 44,945,981 | 44,949,566 | 42 | 2242.85 | 8.65E–73 | 760.49 | 1.16E–24 | 1347.91 | 9.14E–44 |
CLPTM1 | 19q13.32 | 44,954,584 | 44,993,346 | 47 | 2037.76 | 3.42E–60 | 700.13 | 9.56E–21 | 1217.18 | 5.03E–36 |
LINC00158 | 21q21.3 | 25,385,819 | 25,431,701 | 39 | 223.58 | 1.20E–06 | NS | NS | 181.03 | 2.27E–05 |
MIR155HG | 21q21.3 | 25,562,144 | 25,575,168 | 27 | NS | NS | NS | NS | 170.35 | 1.52E–05 |
MIR155 | 21q21.3 | 25,573,979 | 25,574,044 | 22 | NS | NS | NS | NS | 152.69 | 7.00E–06 |
LINC00515 | 21q21.3 | 25,582,774 | 25,583,224 | 24 | NS | NS | NS | NS | 156.49 | 9.36E–06 |
MRPL39 | 21q21.3 | 25,585,655 | 25,607,489 | 36 | NS | NS | NS | NS | 269.62 | 4.20E–06 |
JAM2 | 21q21.3 | 25,639,281 | 25,717,562 | 53 | NS | NS | NS | NS | 276.76 | 3.02E–05 |