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Table 2 Summary of multiple linear regression of age, sex, APOE ε4 genotype, and diagnosis on CSF TMAO level

From: The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease

Variable

β (standard deviation)

t

p value

Age

0.022 (0.004)

6.1

5.6 × 10−8***

Sex

−0.02 (0.06)

−0.03

0.75

APOE ε4 genotype

−0.02 (0.06)

−0.3

0.77

Diagnosis

 Control vs MCI

0.29 (0.11)

2.6

0.01*

 Control vs AD

0.50 (0.11)

4.7

4.1 × 10− 6***

 MCI vs AD

0.21 (0.13)

1.5

0.12

  1. APOE ε4 apolipoprotein E epsilon 4 allele, MCI mild cognitive impairment, AD Alzheimer’s disease
  2. Overall model statistics: F5,404 = 23.1, adjusted R2 = 0.21, p < 2.2 × 10− 16
  3. *p < 0.05
  4. ***p < 0.001
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Alzheimer's Research & Therapy

ISSN: 1758-9193