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Table 2 Summary of multiple linear regression of age, sex, APOE ε4 genotype, and diagnosis on CSF TMAO level

From: The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease

Variable β (standard deviation) t p value
Age 0.022 (0.004) 6.1 5.6 × 10−8***
Sex −0.02 (0.06) −0.03 0.75
APOE ε4 genotype −0.02 (0.06) −0.3 0.77
Diagnosis
 Control vs MCI 0.29 (0.11) 2.6 0.01*
 Control vs AD 0.50 (0.11) 4.7 4.1 × 10− 6***
 MCI vs AD 0.21 (0.13) 1.5 0.12
  1. APOE ε4 apolipoprotein E epsilon 4 allele, MCI mild cognitive impairment, AD Alzheimer’s disease
  2. Overall model statistics: F5,404 = 23.1, adjusted R2 = 0.21, p < 2.2 × 10− 16
  3. *p < 0.05
  4. ***p < 0.001