Fig. 2
From: The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease
Relationship between CSF TMAO and CSF AD biomarkers (a–c) and biomarkers of neuronal degeneration (d–f). CSF TMAO is significantly positively correlated with phosphorylated tau (p-tau), p-tau/Aβ42, total tau (t-tau), and neurofilament light chain protein (NFL), after controlling for age and sex. Scatterplots show individual data points (n = 410) colored by 2D kernel density estimation. Hotter colors represent higher density; black line represents best linear fit between variables; shading represents 95% confidence interval of fit. CSF TMAO expressed as natural log-transformed scaled intensity units (SIU). Aβ, beta-amyloid CSF cerebrospinal fluid, TMAO trimethylamine N-oxide