|
Characteristic
|
Dementia of the Alzheimer type
|
Dementia due to other reasons
|
p value
|
|---|
|
Number
|
23
|
17
| |
|
Gender (male/female)
|
10/13
|
12/5
|
0.116*
|
|
Age (years)
|
69.0 ± 10.9
|
64.4 ± 11.0
|
0.199**
|
|
MMSE
|
22.6 ± 4.4
|
25.3 ± 2.4
|
0.041**
|
|
CDT (points)
|
3.0 ± 1.3
|
2.4 ± 1.2
|
0.147**
|
|
CSF Aβ1–40 (ng/ml)
|
11.87 ± 3.67 (n = 21)
|
10.08 ± 3.43 (n = 15)
|
0.147**
|
|
CSF Aβ1–42 (ng/ml)
|
0.59 ± 0.15 (n = 22)
|
1.20 ± 0.28 (n = 15)
|
< 0.0001**
|
|
CSF Aβ42/40 ratio
|
0.052 ± 0.18 (n = 21)
|
0.126 ± 0.30 (n = 15)
|
< 0.0001**
|
|
CSF tTau (pg/ml)
|
731.6 ± 283.6 (n = 22)
|
300.8 ± 116.5 (n = 15)
|
< 0.0001**
|
|
CSF pTau (pg/ml)
|
85.1 ± 32.0 (n = 22)
|
42.5 ± 12.2 (n = 15)
|
< 0.0001**
|
- Data presented as mean ± standard deviation, unless otherwise stated
- Aβ amyloid beta, CDT clock-drawing test, CSF cerebrospinal fluid, MMSE Mini-Mental State Examination, pTau phosphorylated Tau protein, tTau total Tau protein
- *Fisher’s exact test
- **Unpaired t test for differences between the two diagnostic categories
