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Table 2 Recovery of amyloid-β 1–42, Tau, and pTau181 from 0.1-ml and 0.5-ml aliquots

From: Preanalytical approaches to improve recovery of amyloid-β peptides from CSF as measured by immunological or mass spectrometry-based assays

 1–42 Tau pTau181
YNC AD YNC AD YNC AD
No. of subjects 20 81 20 81 20 81
Mean concentration 0.1 ml (pg/ml) 344 204 55.1 174 30.5 78.2
Mean concentration 0.5 ml (pg/ml) 499 299 58.0 164 29.2 76.8
p Value (mean concentration 0.1 ml vs. 0.5 ml) < 0.0001 < 0.0001 ns < 0.0001 ns 0.021
Mean change from 0.1 ml to 0.5 ml (%) 50.5 52.4 7.59 − 4.77 − 2.42 − 1.74
  1. Abbreviations: Aβ Amyloid-β, AD Alzheimer’s disease, ns Not significant, YNC Young normal control subject
  2. p Values calculated by paired t test