Table 3 Hazard ratios and 95% confidence intervals of all-cause dementia, Alzheimer’s disease, and vascular dementia by number of parameters with high variability measured as coefficient of variation
From: Variability in metabolic parameters and risk of dementia: a nationwide population-based study
Number of parameters | Events (n) | Incidence rate (per 1000 person-years) | Model 1a | Model 2b | Competing risk analysisc |
|---|---|---|---|---|---|
All-cause dementia | |||||
 0 | 6744 | 1.28 | 1 (ref.) | 1 (ref.) | 1 (ref.) |
 1 | 12,195 | 1.99 | 1.23 (1.19–1.27) | 1.22 (1.19–1.26) | 1.22 (1.18–1.25) |
 2 | 9528 | 3.00 | 1.41 (1.37–1.46) | 1.39 (1.35–1.43) | 1.38 (1.33–1.42) |
 3 | 3783 | 4.40 | 1.58 (1.51–1.64) | 1.54 (1.48–1.60) | 1.50 (1.43–1.56) |
 4 | 651 | 6.38 | 1.79 (1.65–1.94) | 1.73 (1.60–1.88) | 1.66 (1.53–1.81) |
P for trend |  | < 0.001 | < 0.001 | < 0.001 | |
Alzheimer’s disease | |||||
 0 | 4952 | 0.94 | 1 (ref.) | 1 (ref.) | 1 (ref.) |
 1 | 9136 | 1.49 | 1.24 (1.20–1.28) | 1.23 (1.19–1.27) | 1.22 (1.18–1.27) |
 2 | 7106 | 2.24 | 1.40 (1.35–1.45) | 1.37 (1.32–1.42) | 1.36 (1.31–1.41) |
 3 | 2818 | 3.28 | 1.55 (1.48–1.62) | 1.50 (1.43–1.57) | 1.46 (1.39–1.53) |
 4 | 474 | 4.64 | 1.71 (1.55–1.88) | 1.65 (1.50–1.81) | 1.58 (1.43–1.74) |
P for trend |  | < 0.001 | < 0.001 | < 0.001 | |
Vascular dementia | |||||
 0 | 815 | 0.16 | 1 (ref.) | 1 (ref.) | 1 (ref.) |
 1 | 1350 | 0.22 | 1.18 (1.09–1.29) | 1.18 (1.08–1.29) | 1.18 (1.08–1.29) |
 2 | 990 | 0.31 | 1.34 (1.22–1.47) | 1.34 (1.22–1.47) | 1.33 (1.21–1.46) |
 3 | 393 | 0.46 | 1.56 (1.38–1.77) | 1.56 (1.38–1.76) | 1.52 (1.35–1.72) |
 4 | 81 | 0.79 | 2.18 (1.73–2.74) | 2.17 (1.72–2.73) | 2.09 (1.66–2.64) |
P for trend |  | < 0.001 | < 0.001 | < 0.001 | |