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Table 3 Association of haemoglobin with global and regional cortical thickness

From: Haemoglobin, magnetic resonance imaging markers and cognition: a subsample of population-based study

Hb (per g/dl decrease)

Global cortical thickness (mm),

β (95% CI)a

Region-specific cortical thickness

Frontal (mm)

β (95% CI)*

Insula (mm)

β (95% CI)*

Occipital (mm)

β (95% CI)*

Temporal (mm)

β (95% CI)*

Limbic (mm)

β (95% CI)*

Parietal (mm)

β (95% CI)*

Model I

− 0.009 (− 0.014, − 0.003)

−0.006 (− 0.012, − 0.001)

−0.007 (− 0.015, 0.001)

−0.015 (− 0.022, − 0.008)

−0.009 (− 0.016, − 0.002)

−0.007 (− 0.013, − 0.001)

−0.009 (− 0.016, − 0.002)

p = 0.002

p = 0.032

p = 0.105

p < 0.001

p = 0.014

p = 0.015

p = 0.010

Model II

−0.006 (− 0.013, − 0.001)

−0.005 (− 0.011, 0.002)

−0.004 (− 0.013, 0.005)

−0.012 (− 0.020, − 0.005)

−0.007 (− 0.014, 0.000)

−0.006 (− 0.012, 0.001)

−0.005 (− 0.013, 0.002)

p = 0.025

p = 0.149

p = 0.426

p = 0.001

p = 0.066

p = 0.076

p = 0.185

Model III

− 0.005 (− 0.011, 0.001)

− 0.003 (− 0.009, 0.003)

−0.001 (− 0.010, 0.008)

−0.011(− 0.019, − 0.004)

−0.005 (− 0.012, 0.003)

−0.004 (− 0.020, 0.012)

− 0.004 (− 0.011, 0.004)

p = 0.091

p = 0.299

p = 0.814

p = 0.003b

p = 0.219

p = 0.185

p = 0.320

  1. Hb haemoglobin
  2. Model I: adjusted for age, gender, race and smoking status
  3. Model II: Model I + hypertension, hyperlipidaemia, diabetes mellitus, glomerular filtration rate and BMI
  4. Model III: Model II + magnetic resonance imaging markers (intracranial volume, lacunes, white matter hyperintensities, cerebral microbleeds, cortical cerebral microinfarcts)
  5. aThe reported confidence interval and p values are for decreased haemoglobin levels. These values are extracted from the multivariable models which also included covariates
  6. bSignificant after Bonferroni correction: p = 0.0083
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Alzheimer's Research & Therapy

ISSN: 1758-9193