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Table 3 Association of haemoglobin with global and regional cortical thickness

From: Haemoglobin, magnetic resonance imaging markers and cognition: a subsample of population-based study

Hb (per g/dl decrease) Global cortical thickness (mm),
β (95% CI)a
Region-specific cortical thickness
Frontal (mm)
β (95% CI)*
Insula (mm)
β (95% CI)*
Occipital (mm)
β (95% CI)*
Temporal (mm)
β (95% CI)*
Limbic (mm)
β (95% CI)*
Parietal (mm)
β (95% CI)*
Model I − 0.009 (− 0.014, − 0.003) −0.006 (− 0.012, − 0.001) −0.007 (− 0.015, 0.001) −0.015 (− 0.022, − 0.008) −0.009 (− 0.016, − 0.002) −0.007 (− 0.013, − 0.001) −0.009 (− 0.016, − 0.002)
p = 0.002 p = 0.032 p = 0.105 p < 0.001 p = 0.014 p = 0.015 p = 0.010
Model II −0.006 (− 0.013, − 0.001) −0.005 (− 0.011, 0.002) −0.004 (− 0.013, 0.005) −0.012 (− 0.020, − 0.005) −0.007 (− 0.014, 0.000) −0.006 (− 0.012, 0.001) −0.005 (− 0.013, 0.002)
p = 0.025 p = 0.149 p = 0.426 p = 0.001 p = 0.066 p = 0.076 p = 0.185
Model III − 0.005 (− 0.011, 0.001) − 0.003 (− 0.009, 0.003) −0.001 (− 0.010, 0.008) −0.011(− 0.019, − 0.004) −0.005 (− 0.012, 0.003) −0.004 (− 0.020, 0.012) − 0.004 (− 0.011, 0.004)
p = 0.091 p = 0.299 p = 0.814 p = 0.003b p = 0.219 p = 0.185 p = 0.320
  1. Hb haemoglobin
  2. Model I: adjusted for age, gender, race and smoking status
  3. Model II: Model I + hypertension, hyperlipidaemia, diabetes mellitus, glomerular filtration rate and BMI
  4. Model III: Model II + magnetic resonance imaging markers (intracranial volume, lacunes, white matter hyperintensities, cerebral microbleeds, cortical cerebral microinfarcts)
  5. aThe reported confidence interval and p values are for decreased haemoglobin levels. These values are extracted from the multivariable models which also included covariates
  6. bSignificant after Bonferroni correction: p = 0.0083