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Table 2 Associations of haemoglobin with markers of cerebral small vessel disease

From: Haemoglobin, magnetic resonance imaging markers and cognition: a subsample of population-based study

Hb (per g/dl decrease)

Cerebral microbleeds

Cortical cerebral microinfarcts

Lacunes

Enlarged perivascular spacesa

WMH volume

(ml)

All microbleeds

OR (95% CI)b

Lobar microbleeds

OR (95% CI)b

Deep microbleeds

OR (95% CI)b

OR (95% CI)b

OR (95% CI)b

OR (95% CI)b

β (95% CI)b

Model I

1.16 (1.02, 1.31)

1.18 (1.04, 1.34)

1.06 (0.90, 1.25)

1.04 (0.82, 1.33)

1.25 (1.07, 1.46)

1.06 (0.91, 1.26)

0.10 (−1.25, 1.44)

p = 0.019

p = 0.011

p = 0.481

p = 0.736

p = 0.004

0.458

p = 0.889

Model II

1.18 (1.03, 1.36)

1.23 (1.06, 1.43)

1.07 (0.88, 1.29)

0.93 (0.72, 1.21)

1.12 (0.94, 1.34)

1.06 (0.89, 1.27)

0.35 (−0.07, 0.76)

p = 0.017

p = 0.006

p = 0.512

p = 0.602

p = 0.198

0.489

p = 0.102

Model III

1.16 (1.01, 1.33)

1.21 (1.04, 1.40)

1.03 (0.85, 1.25)

0.92 (0.70, 1.20)

1.07 (0.89, 1.29)

1.05 (0.88, 1.26)

−0.21 (− 0.19, 0.60)

p = 0.039

p = 0.015c

p = 0.754

p = 0.629

p = 0.467

0.579

p = 0.299

  1. Hb Haemoglobin, WMH White matter hyperintensity
  2. Model I: adjusted for age, gender, race and smoking status
  3. Model II: Model I + hypertension, hyperlipidaemia, diabetes mellitus, glomerular filtration rate and body mass index
  4. Model III: Model II + other magnetic resonance imaging markers
  5. aPresent in a subsample of 536 persons and categorized as ≤ 10 vs. ≥ 11
  6. bThe reported CIs and p values are for decreased haemoglobin levels. These values are extracted from the multivariable models that also included covariates
  7. cSignificant after Bonferroni correction p < 0.025
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Alzheimer's Research & Therapy

ISSN: 1758-9193