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Table 2 Associations of haemoglobin with markers of cerebral small vessel disease

From: Haemoglobin, magnetic resonance imaging markers and cognition: a subsample of population-based study

Hb (per g/dl decrease) Cerebral microbleeds Cortical cerebral microinfarcts Lacunes Enlarged perivascular spacesa WMH volume
(ml)
All microbleeds
OR (95% CI)b
Lobar microbleeds
OR (95% CI)b
Deep microbleeds
OR (95% CI)b
OR (95% CI)b OR (95% CI)b OR (95% CI)b β (95% CI)b
Model I 1.16 (1.02, 1.31) 1.18 (1.04, 1.34) 1.06 (0.90, 1.25) 1.04 (0.82, 1.33) 1.25 (1.07, 1.46) 1.06 (0.91, 1.26) 0.10 (−1.25, 1.44)
p = 0.019 p = 0.011 p = 0.481 p = 0.736 p = 0.004 0.458 p = 0.889
Model II 1.18 (1.03, 1.36) 1.23 (1.06, 1.43) 1.07 (0.88, 1.29) 0.93 (0.72, 1.21) 1.12 (0.94, 1.34) 1.06 (0.89, 1.27) 0.35 (−0.07, 0.76)
p = 0.017 p = 0.006 p = 0.512 p = 0.602 p = 0.198 0.489 p = 0.102
Model III 1.16 (1.01, 1.33) 1.21 (1.04, 1.40) 1.03 (0.85, 1.25) 0.92 (0.70, 1.20) 1.07 (0.89, 1.29) 1.05 (0.88, 1.26) −0.21 (− 0.19, 0.60)
p = 0.039 p = 0.015c p = 0.754 p = 0.629 p = 0.467 0.579 p = 0.299
  1. Hb Haemoglobin, WMH White matter hyperintensity
  2. Model I: adjusted for age, gender, race and smoking status
  3. Model II: Model I + hypertension, hyperlipidaemia, diabetes mellitus, glomerular filtration rate and body mass index
  4. Model III: Model II + other magnetic resonance imaging markers
  5. aPresent in a subsample of 536 persons and categorized as ≤ 10 vs. ≥ 11
  6. bThe reported CIs and p values are for decreased haemoglobin levels. These values are extracted from the multivariable models that also included covariates
  7. cSignificant after Bonferroni correction p < 0.025