Fig. 1

Panel A: Hypothesized relationships. The relationships analyzed in this study are shaded in gray. Functional connectivity, as a proxy of cognitive reserve (CR), may act as a moderator between white matter lesions and cognition. Panel B.0: Regions of interest (ROIs) for each resting state network as provided by CONN atlas. ROIs selected as seeds in the local connectivity measure are presented in grey. Panel B.1: Schematic representation of the assessment of global connectivity measures. Panel B.2: Assessment of local connectivity measure with our behavioral measure of CR indicated by years of education, premorbid intelligence, and lifestyle index. ACC anterior cingulate cortex, AI anterior insula, LP lateral parietal, LPFC lateral prefrontal cortex, MPFC medial prefrontal cortex, PCC posterior cingulate cortex, PPC posterior parietal cortex, WML white matter lesions