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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Neurophysiological signals as predictive translational biomarkers for Alzheimer’s disease treatment: effects of donepezil on neuronal network oscillations in TgF344-AD rats

Fig. 2

Effect of donepezil on stimulation-induced theta phase-gamma amplitude coupling in the hippocampus of urethane anesthetized wild-type (WT) and TgF344-AD rats. Theta-gamma coupling was averaged over all animals in each (a,b) WT and (c,d) TgF344-AD group at both baseline and 30 to 45 min after drug injection. The strength of theta-gamma coupling was expressed by the modulation index (MI). Although baseline theta-gamma coupling was enhanced after donepezil treatment in both WT and TgF344-AD rats at each age group, a significant increase in MI was found only in adult transgenic rats (c, *p < 0.05, two-tailed t test)

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Alzheimer's Research & Therapy

ISSN: 1758-9193