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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Neurophysiological signals as predictive translational biomarkers for Alzheimer’s disease treatment: effects of donepezil on neuronal network oscillations in TgF344-AD rats

Fig. 1

Effect of donepezil on nPO stimulation-induced theta oscillation in the hippocampus of urethane anesthetized adult and aged TgF344-AD rats and their wild-type (WT) counterparts. a Total theta power in the 3–9 Hz frequency band was normalized for each animal to the average power prior to injection (indicated by the arrow) and values grouped according to genotype and age. b Comparison of grouped theta power values obtained during baseline and 30–60 min after donepezil treatment showed a significant increase in theta power in both adult and aged TgF344-AD rats, as well as in aged WT rats (*p < 0.05, two-tailed t test)

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