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Table 3 Multivariate analysis for the correlation of education with cortical thickness

From: The impact of education on cortical thickness in amyloid-negative subcortical vascular dementia: cognitive reserve hypothesis

  Cth_Global Cth_Frontal Cth_Temporal Cth_Parietal Cth_Occipital
B p Value B p Value B p Value B p Value B p Value
PiB(−) svMCI
 Model 1 −0.004 0.352 −0.005 0.278 −0.005 0.283 −0.004 0.310 −0.001 0.800
 Model 2 −0.004 0.375 −0.004 0.438 −0.004 0.398 −0.007 0.146 −0.001 0.880
 Model 3 −0.001 0.823 0.001 0.859 −0.002 0.717 −0.004 0.359 0.001 0.758
PiB(−) SVaD
 Model 1 −0.016 0.028* −0.020 0.019* −0.014 0.115 −0.017 0.014* −0.013 0.047*
 Model 2 −0.020 0.024* −0.023 0.024* −0.019 0.078 −0.021 0.012* −0.016 0.035*
 Model 3 −0.020 0.029* −0.023 0.032* −0.020 0.065 −0.021 0.017* −0.016 0.046*
  1. Abbreviations: Cth cortical thickness, PiB Pittsburgh Compound B, svMCI Subcortical vascular mild cognitive impairment, SVaD Subcortical vascular dementia
  2. * p < 0.05
  3. Multiple linear regression was performed after controlling for the covariates as follows:
  4. Model 1: age, sex, ICV, and MMSE control
  5. Model 2: age, sex, ICV, MMSE, hypertension, diabetes, hyperlipidemia, and smoking control
  6. Model 3: age, sex, ICV, MMSE, hypertension, diabetes, hyperlipidemia, smoking, sqrtWMH, and sqrtLacune control