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Table 1 Demographics and clinical characteristics

From: The impact of education on cortical thickness in amyloid-negative subcortical vascular dementia: cognitive reserve hypothesis

  PiB(−) svMCI (n = 45) PiB(−) SVaD (n = 47) p Value
Demographics
 Age, years 72.1 ± 6.6 71.9 ± 7.2 0.892
 Sex, female, n (%) 29 (64.4) 24 (51.1) 0.194
 Education, years 8.9 ± 5.3 8.5 ± 4.9 0.676
Cardiovascular risk factors, n (%)
 Hypertension 38 (84.4) 37 (78.7) 0.480
 Diabetes mellitus 12 (26.7) 12 (25.5) 0.901
 Hyperlipidemia 14 (31.1) 21 (44.7) 0.180
 Smoker (current/previous/total) 0/11/40 5/12/45 0.112
APOE genotypea, n (%)
 ε2 allele carrier 6/45 (13.3) 5/44 (11.4) 0.778
 ε4 allele carrier 5/45 (11.1) 10/44 (22.7) 0.143
Small vessel MRI markers
 WMH volume, ml 33.8 ± 17.6 41.7 ± 15.4 0.027
 Lacunes, n 8.4 ± 8.6 20.1 ± 18.1 < 0.001
Global PiB retention ratio 1.3 ± 0.1 1.2 ± 0.1 0.085
Intracranial volume, ml 1353.7 ± 102.7 1378.1 ± 132.3 0.329
Mean cortical thickness, mm 2.8 ± 0.1 2.7 ± 0.2 < 0.001
MMSE 26.6 ± 2.4 21.5 ± 4.6 < 0.001
CDR-SOB 1.3 ± 1.0 6.0 ± 3.7 < 0.001
  1. Abbreviations: APOE Apolipoprotein E, CDR-SOB Clinical Dementia Rating Sum of Boxes, MMSE Mini Mental State Examination, MRI Magnetic resonance imaging PiB Pittsburgh compound-B, svMCI Subcortical vascular mild cognitive impairment, SVaD Subcortical vascular dementia, WMH White matter hyperintensity
  2. aAPOE genotyping was performed in 89 of 92 participants. Values are expressed as the mean ± SD or number (%)