The impact of education on cortical thickness in amyloid-negative subcortical vascular dementia: cognitive reserve hypothesis

Table 1 Demographics and clinical characteristics

	PiB(−) svMCI (n = 45)	PiB(−) SVaD (n = 47)	p Value
Demographics
Age, years	72.1 ± 6.6	71.9 ± 7.2	0.892
Sex, female, n (%)	29 (64.4)	24 (51.1)	0.194
Education, years	8.9 ± 5.3	8.5 ± 4.9	0.676
Cardiovascular risk factors, n (%)
Hypertension	38 (84.4)	37 (78.7)	0.480
Diabetes mellitus	12 (26.7)	12 (25.5)	0.901
Hyperlipidemia	14 (31.1)	21 (44.7)	0.180
Smoker (current/previous/total)	0/11/40	5/12/45	0.112
APOE genotype^a, n (%)
ε2 allele carrier	6/45 (13.3)	5/44 (11.4)	0.778
ε4 allele carrier	5/45 (11.1)	10/44 (22.7)	0.143
Small vessel MRI markers
WMH volume, ml	33.8 ± 17.6	41.7 ± 15.4	0.027
Lacunes, n	8.4 ± 8.6	20.1 ± 18.1	< 0.001
Global PiB retention ratio	1.3 ± 0.1	1.2 ± 0.1	0.085
Intracranial volume, ml	1353.7 ± 102.7	1378.1 ± 132.3	0.329
Mean cortical thickness, mm	2.8 ± 0.1	2.7 ± 0.2	< 0.001
MMSE	26.6 ± 2.4	21.5 ± 4.6	< 0.001
CDR-SOB	1.3 ± 1.0	6.0 ± 3.7	< 0.001

Abbreviations: APOE Apolipoprotein E, CDR-SOB Clinical Dementia Rating Sum of Boxes, MMSE Mini Mental State Examination, MRI Magnetic resonance imaging PiB Pittsburgh compound-B, svMCI Subcortical vascular mild cognitive impairment, SVaD Subcortical vascular dementia, WMH White matter hyperintensity
^aAPOE genotyping was performed in 89 of 92 participants. Values are expressed as the mean ± SD or number (%)

ISSN: 1758-9193