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Table 4 Sensitivity, specificity, accuracy, PPV and NPV of the SVM classifier

From: MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker Discovery study

Group Sensitivity Specificity Accuracy PPV NPV Threshold SVM
Optimized sensitivity and specificity
 Cognitively normal 0.61 0.71 0.68 0.41 0.84 0.70
 Mild cognitive impairment 0.71 0.77 0.74 0.84 0.62 0.33
 Whole sample 0.75 0.79 0.77 0.80 0.74 0.48
80% sensitivity
 Cognitively normal 0.80 0.55 0.62 0.41 0.88 0.77
 Mild cognitive impairment 0.80 0.64 0.74 0.79 0.66 0.47
 Whole sample 0.80 0.69 0.75 0.74 0.76 0.56
85% sensitivity
 Cognitively normal 0.85 0.46 0.57 0.38 0.89 0.80
 Mild cognitive impairment 0.85 0.54 0.73 0.75 0.68 0.53
 Whole sample 0.85 0.59 0.73 0.69 0.78 0.64
90% sensitivity
 Cognitively normal 0.90 0.36 0.51 0.35 0.91 0.84
 Mild cognitive impairment 0.90 0.46 0.73 0.73 0.74 0.60
 Whole sample 0.90 0.51 0.71 0.67 0.83 0.70
95% sensitivity
 Cognitively normal 0.95 0.24 0.44 0.32 0.92 0.87
 Mild cognitive impairment 0.95 0.37 0.73 0.71 0.83 0.70
 Whole sample 0.95 0.40 0.69 0.63 0.88 0.79
100% sensitivity
 Cognitively normal 1.00 0.11 0.36 0.30 1.00 0.91
 Mild cognitive impairment 1.00 0.08 0.66 0.64 1.00 0.87
 Whole sample 1.00 0.04 0.54 0.53 1.00 0.95
  1. Results from combined classifier, including demographic information, neuropsychological tests, MRI measures and APOE ε4 genotype. Specific features selected presented in Additional file 1: Table S8. Values averaged across 10-fold cross-validation. Youden’s J statistic employed
  2. APOE apolipoprotein E, MRI magnetic resonance imaging, NPV negative predictive value, PPV positive predictive value, SVM support vector machine