Skip to main content

Advertisement

Table 3 Quantitative MRI measures according to diagnosis and amyloid status

From: MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker Discovery study

MRI measure Cognitively normal Mild cognitive impairment Alzheimer-type dementia F value
Amyloid negative Amyloid positive Amyloid negative Amyloid positive Amyloid negative Amyloid positive Diagnosis Amyloid Diagnosis × amyloid
Hippocampus left 3837 (39) 3752 (58) 3638 (46) 3353 (47)††† 3051 (340) 3124 (61) 32.0*** 0.7 3.5*
Hippocampus right 3960 (53) 3830 (66)# 3760 (57) 3389 (57)††† 3905 (337) 3172 (70)# 19.7*** 12.3*** 5.4**
Amygdala left 1501 (36) 1439 (40)# 1405 (37) 1294 (37)††† 1604 (171) 1188 (42)# 9.2*** 11.0** 2.5
Amygdala right 1567 (52) 1535 (55) 1522 (53) 1398 (53)††† 1612 (183) 1290 (57) 4.6** 6.7** 3.2*
Thalamus left 6834 (101) 6614 (119)# 6951 (107) 6689 (108) 6187 (564) 6787 (126) 1.1 0.04 1.1
Thalamus right 6388 (104) 6320 (113) 6419 (106) 6173 (107)††† 5600 (420) 6185 (117) 2.4 0.4 3.2*
Caudate left 3419 (67) 3336 (80) 3571 (71) 3407 (71) 4151 (393) 3387 (85) 2.9 6.1* 1.7
Caudate right 3491 (88) 3396 (98) 3584 (91) 3463 (91) 4575 (407) 3413 (103)# 3.7* 10.7** 3.4*
Putamen left 4831 (105) 4779 (117) 4689 (108) 4609 (109) 4692 (478) 4509 (122) 2.1 0.4 0.1
Putamen right 4627 (121) 4607 (130) 4659 (123) 4461 (124) 4524 (444) 4302 (134) 0.6 0.9 1.5
Pallidum left 1366 (32) 1412 (37) 1370 (33) 1385 (33) 1488 (168) 1390 (39) 0.3 0.05 0.6
Pallidum right 1388 (26) 1382 (31) 1384 (28) 1379 (28) 1361 (148) 1392 (33) 0.02 0.01 0.03
Accumbens left 465 (23) 432 (24)# 434 (23) 411 (23) 526 (79) 375 (25) 2.1 6.7** 1.5
Accumbens right 497 (22) 467 (23)# 466 (22) 443 (22) 425 (78) 419 (24) 2.3 4.0* 0.6
Average CT 2.29 (0.02) 2.28 (0.02) 2.27 (0.02) 2.22 (0.02)††† 2.22 (0.07) 2.19 (0.02) 5.3** 1.6 1.5
CT Dickerson 2.54 (0.02) 2.52 (0.02) 2.50 (0.02) 2.45 (0.02)†† 2.48 (0.09) 2.38 (0.02) 8.3*** 3.5 1.6
CT Jack 2.68 (0.03) 2.63 (0.03)# 2.63 (0.03) 2.56 (0.03)††† 2.67 (0.10) 2.47 (0.03)# 6.7** 9.3** 1.7
  1. Data presented as estimate (standard error). Estimates derived from linear mixed models including diagnosis × amyloid, age, gender and APOE ε4 genotype as covariates and cohort as random effect
  2. APOE apolipoprotein E, CT cortical thickness, FDR false discovery rate, MRI magnetic resonance imaging
  3. pFDR < 0.05, ††pFDR < 0.01, †††pFDR < 0.001, #puncorrected < 0.05, compared to amyloid negative within diagnostic group
  4. *p < 0.05, **p < 0.01, ***p < 0.001 for F statistic of main effect