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Table 3 Quantitative MRI measures according to diagnosis and amyloid status

From: MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker Discovery study

MRI measure

Cognitively normal

Mild cognitive impairment

Alzheimer-type dementia

F value

Amyloid negative

Amyloid positive

Amyloid negative

Amyloid positive

Amyloid negative

Amyloid positive

Diagnosis

Amyloid

Diagnosis × amyloid

Hippocampus left

3837 (39)

3752 (58)

3638 (46)

3353 (47)†††

3051 (340)

3124 (61)

32.0***

0.7

3.5*

Hippocampus right

3960 (53)

3830 (66)#

3760 (57)

3389 (57)†††

3905 (337)

3172 (70)#

19.7***

12.3***

5.4**

Amygdala left

1501 (36)

1439 (40)#

1405 (37)

1294 (37)†††

1604 (171)

1188 (42)#

9.2***

11.0**

2.5

Amygdala right

1567 (52)

1535 (55)

1522 (53)

1398 (53)†††

1612 (183)

1290 (57)

4.6**

6.7**

3.2*

Thalamus left

6834 (101)

6614 (119)#

6951 (107)

6689 (108)†

6187 (564)

6787 (126)

1.1

0.04

1.1

Thalamus right

6388 (104)

6320 (113)

6419 (106)

6173 (107)†††

5600 (420)

6185 (117)

2.4

0.4

3.2*

Caudate left

3419 (67)

3336 (80)

3571 (71)

3407 (71)†

4151 (393)

3387 (85)

2.9

6.1*

1.7

Caudate right

3491 (88)

3396 (98)

3584 (91)

3463 (91)

4575 (407)

3413 (103)#

3.7*

10.7**

3.4*

Putamen left

4831 (105)

4779 (117)

4689 (108)

4609 (109)

4692 (478)

4509 (122)

2.1

0.4

0.1

Putamen right

4627 (121)

4607 (130)

4659 (123)

4461 (124)†

4524 (444)

4302 (134)

0.6

0.9

1.5

Pallidum left

1366 (32)

1412 (37)

1370 (33)

1385 (33)

1488 (168)

1390 (39)

0.3

0.05

0.6

Pallidum right

1388 (26)

1382 (31)

1384 (28)

1379 (28)

1361 (148)

1392 (33)

0.02

0.01

0.03

Accumbens left

465 (23)

432 (24)#

434 (23)

411 (23)

526 (79)

375 (25)

2.1

6.7**

1.5

Accumbens right

497 (22)

467 (23)#

466 (22)

443 (22)

425 (78)

419 (24)

2.3

4.0*

0.6

Average CT

2.29 (0.02)

2.28 (0.02)

2.27 (0.02)

2.22 (0.02)†††

2.22 (0.07)

2.19 (0.02)

5.3**

1.6

1.5

CT Dickerson

2.54 (0.02)

2.52 (0.02)

2.50 (0.02)

2.45 (0.02)††

2.48 (0.09)

2.38 (0.02)

8.3***

3.5

1.6

CT Jack

2.68 (0.03)

2.63 (0.03)#

2.63 (0.03)

2.56 (0.03)†††

2.67 (0.10)

2.47 (0.03)#

6.7**

9.3**

1.7

  1. Data presented as estimate (standard error). Estimates derived from linear mixed models including diagnosis × amyloid, age, gender and APOE ε4 genotype as covariates and cohort as random effect
  2. APOE apolipoprotein E, CT cortical thickness, FDR false discovery rate, MRI magnetic resonance imaging
  3. †pFDR < 0.05, ††pFDR < 0.01, †††pFDR < 0.001, #puncorrected < 0.05, compared to amyloid negative within diagnostic group
  4. *p < 0.05, **p < 0.01, ***p < 0.001 for F statistic of main effect
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Alzheimer's Research & Therapy

ISSN: 1758-9193